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Titolo:
Treatment of tension-type headache with botulinum toxin type A: A double-blind, placebo-controlled study
Autore:
Rollnik, JD; Tanneberger, O; Schubert, M; Schneider, U; Dengler, R;
Indirizzi:
Hannover Med Sch, Dept Neurol, D-30623 Hannover, Germany Hannover Med SchHannover Germany D-30623 rol, D-30623 Hannover, Germany Hannover Med Sch, Dept Neurol & Clin Neurophysiol, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 iol, D-30623 Hannover, Germany Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 apy, D-30623 Hannover, Germany
Titolo Testata:
HEADACHE
fascicolo: 4, volume: 40, anno: 2000,
pagine: 300 - 305
SICI:
0017-8748(200004)40:4<300:TOTHWB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; SPASMODIC TORTICOLLIS; GENERAL-POPULATION; MUSCLE TENDERNESS; MYOFASCIAL PAIN; A TOXIN; EPIDEMIOLOGY; INJECTIONS; MIGRAINE; IMPACT;
Keywords:
tension-type headache; therapy; botulinum toxin A; muscle tenderness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rollnik, JD Hannover Med Sch, Dept Neurol, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 Hannover, Germany
Citazione:
J.D. Rollnik et al., "Treatment of tension-type headache with botulinum toxin type A: A double-blind, placebo-controlled study", HEADACHE, 40(4), 2000, pp. 300-305

Abstract

Objective.-To determine whether injections of botulinum toxin could be of therapeutic value in the treatment of tension-type headache. Background.-Botulinum toxin A is very effective at reducing muscle tenderness and pain In many diseases. Increased muscle tension may contribute to tension-type headache. Methods.-We performed a double-blind, placebo-controlled study with 21 patients fulfilling the International Headache Society criteria for tension-type headache. Participants were randomly assigned to treatment (pericranial injection of 10 x 20 mouse units botulinum toxin A) or placebo (injection of isotonic saline in the same manner). Results.-After 4, 8, and 12 weeks, no significant differences between placebo and treatment could he observed (with respect to visual analog scale, frequency and duration of headache attacks, consumption of analgesics, pressure pain threshold, total tenderness score, and quality-of-life parameters). Conclusions.-The findings of our study strongly support the hypothesis that peripheral mechanisms, such as increased muscle tenderness, only play a minor role in the pathogenesis of tension-type headache.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:35:32