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Titolo:
Invasion of a multitude of genetic niches by mobile endonuclease genes
Autore:
Gimble, FS;
Indirizzi:
Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr Genome Res, Houston, TX 77030 USA Texas A&M Univ Houston TX USA 77030 Ctr Genome Res, Houston, TX 77030 USA
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 2, volume: 185, anno: 2000,
pagine: 99 - 107
SICI:
0378-1097(20000415)185:2<99:IOAMOG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-I INTRON; ENCODED HOMING ENDONUCLEASE; PROTEIN-SPLICING DOMAIN; DNA ENDONUCLEASE; SACCHAROMYCES-CEREVISIAE; SELECTIVE ADVANTAGE; INTEINS; BINDING; EVOLUTION; SEQUENCES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Gimble, FS Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr GenomeRes, 2121 W Holcombe Blvd, Houston, TX 77030 USA Texas A&M Univ 2121 W Holcombe Blvd Houston TX USA 77030 30 USA
Citazione:
F.S. Gimble, "Invasion of a multitude of genetic niches by mobile endonuclease genes", FEMS MICROB, 185(2), 2000, pp. 99-107

Abstract

Persistence of a mobile DNA element in a population reflects a balance between the ability of the host to eliminate the element and the ability of the element to survive and to disseminate to other individuals. Tn each of the three biological kingdoms, several families of a mobile DNA element have been identified which encode a single protein that acts on nucleic acids. Collectively termed homing endonuclease genes (HEGs), these elements employ varied strategies to ensure their survival. Some members of the HEG families have a minimal impact on host fitness because they associate with genes having self-splicing introns or inteins that remove the HEGs at the RNA or protein level. The HEG and the intron/intein gene spread throughout the population by a gene conversion process initiated by the HEG-encoded endonuclease called 'homing' in which the HEG and intron/intein genes are copied to cognate alleles that lack them. The endonuclease activity also contributes to a high frequency of lateral transmission of HEGs between species as has been documented in plants and other systems. Other HEGs have positive selection value because the proteins have evolved activities that benefit their host organisms. The success of HEGs in colonizing diverse genetic niches results from the flexibility of the encoded endonucleases in adopting new specificities. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:22:57