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Titolo:
Role of the pretectal nucleus of the optic tract in short-latency ocular following responses in monkeys
Autore:
Inoue, Y; Takemura, A; Kawano, K; Mustari, MJ;
Indirizzi:
Electrotech Lab, Neurosci Sect, Tsukuba, Ibaraki 3058568, Japan Electrotech Lab Tsukuba Ibaraki Japan 3058568 uba, Ibaraki 3058568, Japan Natl Inst Physiol Sci, Dept Integrat Physiol, Okazaki, Aichi 4448585, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 i, Aichi 4448585, Japan Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 eg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ, Dept Neurol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Univ, Dept Neurol, Atlanta, GA 30322 USA
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 3, volume: 131, anno: 2000,
pagine: 269 - 281
SICI:
0014-4819(200004)131:3<269:ROTPNO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL TERMINAL NUCLEUS; CEREBELLAR VENTRAL PARAFLOCCULUS; TEMPORAL FIRING PATTERNS; PURKINJE-CELLS; OPTOKINETIC NYSTAGMUS; ALERT MONKEY; AFTER-NYSTAGMUS; NEURAL ACTIVITY; MACAQUE MONKEY; EYE-MOVEMENTS;
Keywords:
ocular-following; pretectum; nystagmus; monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kawano, K Electrotech Lab, Neurosci Sect, 1-1-4 Umezono, Tsukuba, Ibaraki 3058568, Japan Electrotech Lab 1-1-4 Umezono Tsukuba Ibaraki Japan 3058568 apan
Citazione:
Y. Inoue et al., "Role of the pretectal nucleus of the optic tract in short-latency ocular following responses in monkeys", EXP BRAIN R, 131(3), 2000, pp. 269-281

Abstract

When a large-field image is suddenly moved in front of an observer, an ocular following response (OFR) with short latency (<60 ms in monkey and <85 ms in human) is observed. Previous studies have shown that neurons in the pretectal nucleus of the optic tract (NOT) of the monkey respond to movementsof large-field visual stimuli. To understand the potential role of the NOTin the OFR, we first recorded single-unit activity in the NOT of four monkeys (Macaca fuscata). Sixty-six NOT neurons preferred large-field ipsiversive visual motion. In 86% (49/57) of the neurons, optimal directions were distributed over +/-30 degrees from ipsilateral. NOT units were sensitive to the speed of the visual motion; 54% (27/50) preferred slow (less than or equal to 20 degrees/s), 22% (11/50) preferred fast (greater than or equal to 80 degrees/s) and the remainder intermediate speeds. Their response latencies to the moving visual scene were very short (similar to 51 ms), and 44% of them led the onset of the OFR by 10 ms or more. To characterize the response properties of these neurons, we reconstructed the temporal firing patterns of 17 NOT neurons, using the acceleration, velocity, position and bias components of retinal image slip or eye movements during the OFR by a leastsquares error method. For each stimulus speed fitting condition, using either retinal slip or eye movements, their firing patterns were matched to some extent although the goodness of fit was better using retinal slip than when eye movements were used. Neither of these models could be applied independently of stimulus speed, suggesting that the firing pattern of the NOT neurons represented information associated with retinal slip or eye movements during the OFR, over a limited range. To provide further evidence that the NOT is involved in generating the OFR, we placed unilateral microinjections of muscimol into the NOT. Following the muscimol injection, we observed a similar to 50% decrease in eye velocity of the OFR toward the side of injection regardless of stimulus speed, while only a weak effect was observed in the OFR during contraversive or vertical image motion. These results suggest that the NOT may play a role in the initiation and support of the short-latency ocular following response. (C) Springer-Verlag 2000.

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Documento generato il 20/01/20 alle ore 10:38:20