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Titolo:
Relationships between antisocial personality and alcoholism: genetic hypotheses
Autore:
Limosin, F; Ades, J; Gorwood, P;
Indirizzi:
Hop Louis Mourier, Psychiat Serv, F-92701 Colombes, France Hop Louis Mourier Colombes France F-92701 Serv, F-92701 Colombes, France
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 2, volume: 15, anno: 2000,
pagine: 123 - 128
SICI:
0924-9338(200003)15:2<123:RBAPAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET MAO ACTIVITY; MONOAMINE-OXIDASE ACTIVITY; CROSS-FOSTERING ANALYSIS; CEREBROSPINAL-FLUID; FAMILIAL TRANSMISSION; PSYCHIATRIC-DISORDERS; ENVIRONMENTAL-FACTORS; MULTIFACTORIAL MODEL; DISEASE TRANSMISSION; GENERAL-POPULATION;
Keywords:
alcoholism; antisocial personality; co-morbidity; genetic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Limosin, F Hop Louis Mourier, Psychiat Serv, 178 Rue Renouillers, F-92701 Colombes, France Hop Louis Mourier 178 Rue Renouillers Colombes France F-92701
Citazione:
F. Limosin et al., "Relationships between antisocial personality and alcoholism: genetic hypotheses", EUR PSYCHIA, 15(2), 2000, pp. 123-128

Abstract

Genetic factors explain a non-negligible part of the vulnerability to alcohol dependence, the genetic influence in males being estimated at around 60%. The search for gene(s) potentially implicated in alcoholism is counteracted by the clinical heterogeneity of alcoholism, but also by heterogeneity of the etiologic factors involved. It is thus necessary to redefine more specific phenotypes with more simple determinism, and to focus on more specific subsets of candidate genes. In this view. the existence of co-occurrence(presence at the same time, whatever the cause) between antisocial personality and alcoholism is frequently reported. Three hypotheses have been previously proposed to explain this co-occurrence. Firstly, it could be a pure artefact or contamination, due to common items in diagnostic manuals widelyused, such as the DSM or ICD. Secondly, antisocial personality and alcoholism could share common etiologic factor(s), and determine a 'real' co-morbidity. Finally, common genetic factors between these two disorders may exist, with the observation of a co-transmission of both disorders more often than expected by chance alone, meaning the existence of co-aggregation. Each of these three hypotheses will be reviewed and discussed. (C) 2000 Editionsscientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:23:41