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Titolo:
Genetic vulnerability to drug abuse
Autore:
Duaux, E; Krebs, MO; Loo, H; Poirier, MF;
Indirizzi:
Hop St Anne, Serv Hosp Univ Sante Mentale & Therapeut, F-75014 Paris, France Hop St Anne Paris France F-75014 tale & Therapeut, F-75014 Paris, France
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 2, volume: 15, anno: 2000,
pagine: 109 - 114
SICI:
0924-9338(200003)15:2<109:GVTDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; NATIONAL COMORBIDITY SURVEY; DOPAMINE-RECEPTOR GENE; EXON-III POLYMORPHISM; NOVELTY SEEKING; SUBSTANCE-ABUSE; NO ASSOCIATION; COCAINE DEPENDENCE; ALCOHOL; PERSONALITY;
Keywords:
addiction; allele; association; drug abuse; genetics; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Duaux, E Hop St Anne, Serv Hosp Univ Sante Mentale & Therapeut, F-75014 Paris, France Hop St Anne Paris France F-75014 erapeut, F-75014 Paris, France
Citazione:
E. Duaux et al., "Genetic vulnerability to drug abuse", EUR PSYCHIA, 15(2), 2000, pp. 109-114

Abstract

Addiction to various substances, including drugs and alcohol, probably arises from a combination of environmental and genetic factors. The genetic vulnerability to drug addiction is supported by several familiar, adoption and twin studies. However, as in other mental disorders, the genetic vulnerability to drug addiction appears complex: these disorders do not follow the rules of Mendelian inheritance. Instead, they are probably influenced by multiple susceptibility genes, each of which contributes to the disorder. Themore genes necessary for a disorder, the harder it is to detect any of them. This difficulty is magnified by the role of environmental factors. Association studies using the candidate gene approach can identify susceptibility genes for drug abuse supported by the pathophysiological hypothesis of the illness. This review will focus on the clinical and molecular genetic studies in drug abuse. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:57:18