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Titolo:
The DRD2 gene and the risk for alcohol dependence in bipolar patients
Autore:
Gorwood, P; Bellivier, F; Ades, J; Leboyer, M;
Indirizzi:
Hop Louis Mourier, Serv Psychiat Adulte Prof Ades, F-92700 Colombes, France Hop Louis Mourier Colombes France F-92700 Ades, F-92700 Colombes, France Lab Personnal & Conduites Adaptat Prof Jouvent, CNRS UMR 7593, Paris, France Lab Personnal & Conduites Adaptat Prof Jouvent Paris France ris, France Hop Albert Chenevier & Henri Mondor, AP HP, Serv Psychiat Adulte Prof Rouillon, F-94000 Creteil, France Hop Albert Chenevier & Henri Mondor CreteilFrance F-94000 eteil, France INSERM U513, Lab Neurobiol & Psychiat, F-94000 Creteil, France INSERM U513 Creteil France F-94000 l & Psychiat, F-94000 Creteil, France
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 2, volume: 15, anno: 2000,
pagine: 103 - 108
SICI:
0924-9338(200003)15:2<103:TDGATR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANIC-DEPRESSIVE ILLNESS; DOPAMINE-D2 RECEPTOR GENES; AFFECTIVE-DISORDER; TYROSINE-HYDROXYLASE; DRUG-ABUSE; LINKAGE; ASSOCIATION; LOCUS; ALLELES; D-2;
Keywords:
alcoholism; co-morbidity; genetics; mood disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Gorwood, P Hop Louis Mourier, Psychiat Serv, 178 Rue Renouillers, F-92701 Colombes, France Hop Louis Mourier 178 Rue Renouillers Colombes France F-92701
Citazione:
P. Gorwood et al., "The DRD2 gene and the risk for alcohol dependence in bipolar patients", EUR PSYCHIA, 15(2), 2000, pp. 103-108

Abstract

The high co-morbidity between bipolar disorder and alcohol dependence may have different explanations, one of them being the existence of common genetic factors for the two disorders. Several candidate genes may be involved but the genes acting in the dopaminergic pathway may be more specifically involved. We have thus tested the role of the gene encoding the D2 dopamine receptor (Taql Al allele) in the potentially shared vulnerability to alcohol dependence and bipolar disorder. One hundred and twenty-two French (for at least two generations) patients were recruited on the basis of hospital or outpatient files and were interviewed with the DIGS. The Al allele frequencies were compared between four groups, namely, with bipolar patients and co-morbid alcohol dependence (N = 21), with bipolar patients without alcohol morbidity (N = 31), with alcohol dependence without mood disorder (N = 35) and unaffected controls (N = 35). The Hardy Weinberg equilibrium for the DRD2 Taql Al genotypes was respected for the sample as a whole, and for each subsample. We observed that 42.9% of control subjects have at least one Al allele, a frequency which is not significantly different from the one observed in the affected sample as a whole (39.1%), neither from patients withalcohol dependence (37.1%), patients with bipolar disorder (48.4%) nor patients with alcohol dependence and bipolar disorder (28.6%). The regression analysis based on the three variables (bipolar disorder, alcohol dependenceand interaction between these two disorders) does not explain the presenceof the Al allele of the DRD2 gene. We thus found no evidence for a significant role of the Al allele of the D2 dopamine receptor gene in the specificassociation between bipolar disorder and alcohol dependence in our sample. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 25/01/20 alle ore 18:40:53