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Titolo:
Clinical evaluation of no-carrier-added meta-[I-123]iodobenzylguanidine for myocardial scintigraphy
Autore:
Knickmeier, M; Matheja, P; Wichter, T; Schafers, KP; Kies, P; Breithardt, G; Schober, O; Schafers, M;
Indirizzi:
Univ Munster, Dept Nucl Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Nucl Med, D-48129 Munster, Germany Univ Munster, Dept Cardiol & Angiol, D-4400 Munster, Germany Univ MunsterMunster Germany D-4400 ol & Angiol, D-4400 Munster, Germany Univ Munster, Inst Arteriosclerosis Res, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 lerosis Res, D-4400 Munster, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 27, anno: 2000,
pagine: 302 - 307
SICI:
0340-6997(200003)27:3<302:CEONMF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
METAIODOBENZYLGUANIDINE; CARDIOMYOPATHY; HEART;
Keywords:
single-photon emission tomography; presynaptic sympathetic innervation; no-carrier-added MIBG; heart; tachyarrhythmias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Knickmeier, M Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
M. Knickmeier et al., "Clinical evaluation of no-carrier-added meta-[I-123]iodobenzylguanidine for myocardial scintigraphy", EUR J NUCL, 27(3), 2000, pp. 302-307

Abstract

In clinical and research studies, images obtained using carrier-added meta-[I-123]iodobenzylguanidine (c.a. [I-123]MIBG) have shown quite variable quality, with varying levels of uptake in lung, liver and mediastinum; this is a significant problem for quantification of the myocardial uptake by means of region ratios. First experimental and preliminary human data in respect of no-carrier-added (n.c.a.) [I-123]MIBG are indicative of improved imaging quality, The aim of the present study was to evaluate the clinical valueof myocardial scintigraphy with n.c.a. [I-123]MIBG in patients with tachyarrhythmias. The study population comprised 24 patients with tachyarrhythmogenic diseases routinely studied by cardiac single-photon emission tomography (SPET) with [I-123]MIBG. Twelve of the 24 patients were studied with c.a.[I-123]MIBG (seven females and five males; mean age 42+/-13 years, range 20-60 years), whereas the other 12 were studied with n.c.a. [I-123]MIBG (tenfemales, two males; mean age 41+/-11 years, range 18-60 years, P=NS). For quantification of the specific uptake in the different organs, count ratioswere calculated on SPET images acquired 4 h p.i. Visual analysis of all [I-123]MIBG scans showed improved image quality (improved contrast between heart and neighbouring organs) in n.c.a. studies as compared with c.a. studies. A significantly higher heart/left atrial blood ratio was found in the n.c.a, studies as compared with the c.a. studies (10.3+/-3.2 vs 5.3+/-1.3, P=0.0003); furthermore, significantly higher heart/lung and heart/liver ratios (2.5+/-0.6 vs 1.5+/-0.3, P=0.0002, and 0.8+/-0.2 vs 0.6+/-0.1, P=0.0006, respectively) were obtained in the c.a. studies, whereas lung/left atrial blood and liver/left atrial blood ratios showed no significant differences (4.2+/-1.3 vs 3.6+/-1.1, P=0.39, and 13.7+/-5.2 vs 9.6+/-2.2, P=0.21, respectively). In conclusion, the use of n.c.a. [I-123]MIBG yields a significantly higher myocardial uptake associated with improvement in contrast between the heart and neighbouring organs and is therefore superior to the commercially available c.a. [I-123]MIBG for use in clinical and research studies ofthe myocardial presynaptic sympathetic nervous system. Furthermore, our data indicate that for quantification the use of a left atrial blood reference region of interest, which is only available on SPET studies, is to be recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:38:05