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Titolo:
The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
Autore:
Barlocco, D; Cignarella, G; Giardina, GAM; Toma, L;
Indirizzi:
Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy Univ Milan Milan Italy I-20131 armaceut & Tossicol, I-20131 Milan, Italy SmithKline Beecham SpA, Dept Med Chem, I-20021 Milan, Italy SmithKline Beecham SpA Milan Italy I-20021 ed Chem, I-20021 Milan, Italy Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 rtimento Chim Organ, I-27100 Pavia, Italy
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 3, volume: 35, anno: 2000,
pagine: 275 - 282
SICI:
0223-5234(200003)35:3<275:TO1(AA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCICEPTIN ORPHANIN FQ; HAMSTER OVARY CELLS; TISSUE DISTRIBUTION; ENDOGENOUS LIGAND; SPINAL-CORD; HYPERALGESIA; BINDING; AGONIST; PEPTIDE; RAT;
Keywords:
analgesia; opioid-receptor-like 1 (ORL-1); nociceptin; orphanin FQ;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Barlocco, D Univ Milan, Ist Chim Farmaceut & Tossicol, Viale Abruzzi 42, I-20131 Milan, Italy Univ Milan Viale Abruzzi 42 Milan Italy I-20131 Milan, Italy
Citazione:
D. Barlocco et al., "The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics", EUR J MED C, 35(3), 2000, pp. 275-282

Abstract

A new sequence, which encoded a novel G protein-coupled receptor, was disclosed by two different groups, using the nucleic acid probes based on the delta opioid receptor, first cloned in 1992. The new receptor, which Meuniercalled opioid-receptor-like 1 (ORL-1), was shown to share high homology with the opioid receptors and therefore thought to be a potential target for new analgesics. In this respect, the present review reports on the literature referring to ORL-1, to its natural ligand (nociceptin or orphanin FQ) and to several synthetic analogues recently described, both as agonists or antagonists at the receptor. (C) 2000 Editions scientifiques er medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:27:29