Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
P53, C-ERBB-2 AND NM23 EXPRESSION HAVE NO PROGNOSTIC-SIGNIFICANCE IN PRIMARY PULMONARY ADENOCARCINOMA
Autore:
MACKINNON M; KERR KM; KING G; KENNEDY MM; COCKBURN JS; JEFFREY RR;
Indirizzi:
ABERDEEN ROYAL INFIRM,DEPT PATHOL ABERDEEN SCOTLAND ABERDEEN ROYAL INFIRM,DEPT PATHOL ABERDEEN SCOTLAND ABERDEEN ROYAL INFIRM,DEPT CARDIOTHORAC SURG ABERDEEN SCOTLAND
Titolo Testata:
European journal of cardio-thoracic surgery
fascicolo: 5, volume: 11, anno: 1997,
pagine: 838 - 841
SICI:
1010-7940(1997)11:5<838:PCANEH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPRESSOR GENE; LUNG ADENOCARCINOMAS; SHORTENED SURVIVAL; PROTEIN EXPRESSION; TUMOR PATHOLOGY; METASTASIS; CARCINOMA; CANCER; OVEREXPRESSION; PRODUCT;
Keywords:
LUNG; ADENOCARCINOMA; IMMUNOHISTOCHEMISTRY; NM23; P53; C-ERBB-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Mackinnon et al., "P53, C-ERBB-2 AND NM23 EXPRESSION HAVE NO PROGNOSTIC-SIGNIFICANCE IN PRIMARY PULMONARY ADENOCARCINOMA", European journal of cardio-thoracic surgery, 11(5), 1997, pp. 838-841

Abstract

Objective: We analysed nm23, c-erbB-2 and p53 protein expression in lung adenocarcinoma in relation to clinicopathological status and patient survival, to elucidate any potential prognostic value. Published reports suggest that high p53 and c-erbB-2 protein expression and loss of nm23 protein expression are associated with poor prognosis. Methods:A total of 162 pulmonary adenocarcinomas resected between 1980 and 1991 were stained using monoclonal antibodies to nm23 (NCL-nm23), c-erbB-2 (NCL-CB11) and p53 (DAKO Do7). Antigen retrieval was by microwave heating and bound antibody was visualised using standard immunohistochemical methods. Staining was scored by two observers blinded to tumour status and patient survival. Results: Of the tumours, 101/162 (62.3%) exhibited high-level p53 expression, 30 (18.5%) showed high-level c-erbB-2 membrane staining, and 77 (47.5%) demonstrated loss of nm23 positivity. The influence of T and N status and disease stage on postoperative survival was as expected. The predicted effect on patient survivalof nm23, c-erbB-2 or nm23 protein expression suggested by previous studies was not verified by our work. This was true both overall and forgroups within the same T or N status or stage. Conclusion: Immunohistochemical assessment of the nm23, c-erbB-2 and p53 proteins using the above monoclonal antibodies does not have value as an independent prognostic indicator in pulmonary adenocarcinoma. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 17:54:55