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Titolo:
Fusarium infections of the skin
Autore:
Gupta, AK; Baran, R; Summerbell, RC;
Indirizzi:
Sunnybrook & Womens Coll, Hlth Sci Ctr, Dept Med, Div Dermatol, Toronto, ON, Canada Sunnybrook & Womens Coll Toronto ON Canada Dermatol, Toronto, ON, Canada
Titolo Testata:
CURRENT OPINION IN INFECTIOUS DISEASES
fascicolo: 2, volume: 13, anno: 2000,
pagine: 121 - 128
SICI:
0951-7375(200004)13:2<121:FIOTS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASIVE PULMONARY ASPERGILLOSIS; BONE-MARROW TRANSPLANTATION; ACUTE-LEUKEMIA; SOLANI INFECTION; IMMUNOCOMPROMISED CHILD; SURVEILLANCE CULTURES; NEUTROPENIC PATIENTS; CLINICAL-FEATURES; FUNGAL-INFECTIONS; ULCERATED LEGS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, AK 490 Wonderland Rd,S Suite 6, London, ON N6K 1L6, Canada 490 Wonderland Rd,S Suite 6 London ON Canada N6K 1L6 L6, Canada
Citazione:
A.K. Gupta et al., "Fusarium infections of the skin", CURR OPIN I, 13(2), 2000, pp. 121-128

Abstract

Fusarium species are ubiquitous and may be found in the soil, air and on plants. Fusarium species can cause mycotoxicosis in humans following ingestion of food that has been colonized by the fungal organism. In humans, Fusarium species can also cause disease that is localized, focally invasive or disseminated. The pathogen generally affects immunocompromised individuals with infection of immunocompetent persons being rarely reported. Localized infection includes septic arthritis, endophthalmitis, osteomyelitis, cystitis and brain abscess. In these situations relatively good response may be expected following appropriate surgery and oral antifungal therapy. Disseminated infection occurs when two or more noncontiguous sites are involved. Over eighty cases have been reported, many of which had a hematologic malignancy including neutropenia. The species most commonly involved include Fusarium solani, Fusarium oxysporum, and Fusarium moniliforme (also termed F. verticillioides). The diagnosis of Fusarium infection may be made on histopathology, gram stain, mycology, blood culture, or serology. Portals of entry of disseminated infection include the respiratory tract, the gastrointestinal tract, and cutaneous sites. The skin can be an important and an early clue to diagnosis since cutaneous lesions may be observed at an early stage of the disease and in about seventy-five cases of disseminated Fusarium infection. Typical skin lesions may be painful red or violaceous nodules, the center of which often becomes ulcerated and covered by a black eschar. The multiple necrotizing lesions are often observed on the trunk and the extremities. Onychomycosis most commonly due to F. oxysporum or F. solani has been reported. The onychomycosis may be of several types: distal and lateral subungual (DLSO), white superficial (WSO), and proximal subungual (PSO). In proximal subungual onychomycosis there may be associated leukonychia and/or periungual inflammation. Patients with Fusarium onychomycosis have been cured following therapy with itraconazole, terbinafine, ciclopirox olamine lacquer, or topical antifungal agent. In other instances nail avulsion plus antifungal therapy has been successful. In patients with hematologic malignancy or bone marrow transplant, who may experience prolonged or severe neutropenia during the course of therapy, the skin and nails should be carefully examined and consideration given to treating potential infection sites that may serve as portals for systemic dissemination. When disseminated Fusarium infection is present therapywith antifungal agents has generally been disappointing with the chances of a successful resolution being enhanced if the neutropenia can be corrected in a timely manner. Curr Opin Infect Dis 13:121-128. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:05:41