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Titolo:
SULFATION AND SULFOTRANSFERASES .5. THE IMPORTANCE OF 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) IN THE REGULATION OF SULFATION
Autore:
KLAASSEN CD; BOLES JW;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,CTR ENVIRONM &OCCUPAT HLTH KANSAS CITY KS 66160
Titolo Testata:
The FASEB journal
fascicolo: 6, volume: 11, anno: 1997,
pagine: 404 - 418
SICI:
0892-6638(1997)11:6<404:SAS.TI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE; BORDER MEMBRANE-VESICLES; PERFUSED-RAT-LIVER; INCREASED INORGANIC SULFATE; ANION TRANSPORT INHIBITORS; DEFICIENT DIETARY-INTAKE; STEADY-STATE KINETICS; ATP-SULFURYLASE; PENICILLIUM-CHRYSOGENUM; SACCHAROMYCES-CEREVISIAE;
Keywords:
ACETAMINOPHEN; SULFATE; ATP-SULFURYLASE; APS-KINASE; GLUTATHIONE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
116
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Klaassen e J.W. Boles, "SULFATION AND SULFOTRANSFERASES .5. THE IMPORTANCE OF 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) IN THE REGULATION OF SULFATION", The FASEB journal, 11(6), 1997, pp. 404-418

Abstract

Sulfation is the transfer of a sulfate group from 3'-phosphoadenosine5'-phosphosulfate (PAPS) to a substrate that is catalyzed by a familyof sulfotransferase enzymes. Many different endogenous and xenobioticmolecules are substrates for the sulfotransferases; sulfation affectsmany different physiological processes, including: I) deactivation and bioactivation of xenobiotics, 2) inactivation of hormones and catecholamines, 3) structure and function of macromolecules, and 4) elimination of end products of catabolism. PAPS is the obligate cosubstrate that is synthesized in tissues to make available an ''activated form'' of sulfate for the sulfation reaction. PAPS participation in the reaction is dependent on its availability, which in turn is dependent on itssynthesis, degradation, and ultimately its utilization in the sulfation reaction itself. PAPS synthesis is dependent on the availability ofsulfate and on the activity of the two enzymes of its synthesis, ATP-sulfurylase and APS-kinase. Although the kinetic properties of these two enzymes are well described, their in vivo regulation is not fully understood. Sulfation is a high-affinity, low-capacity enzymatic process in which the entire liver content of PAPS can be consumed in less than 2 min. ATP-sulfurylase and APS-kinase can rapidly synthesize additional PAPS. The low capacity of sulfation in rats is due to the Limitedavailability of sulfate, whereas in mice the sulfotransferases appearto limit sulfation capacity. Sulfation rates are not readily enhanced, but they can be decreased. 2,6-Dichloro-4-nitrophenol inhibits phenolsulfotransferases, but not hydroxysteroid-sulfotransferases. However,the sulfation of phenols and hydroxysteroids can be decreased by factors that decrease sulfate availability such as a low-sulfate diet, other xenobiotics that are sulfated, and molybdate, which inhibits sulfate intestinal absorption, renal reabsorption, and sulfate incorporationinto PAPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:57:08