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Titolo:
In vitro fusion of human inguinal hernia with associated epithelial transformation
Autore:
Hutson, JM; Albano, FR; Paxton, G; Sugita, Y; Connor, R; Clarnette, TD; Gray, AZ; Watts, LM; Farmer, PJ; Hasthorpe, S;
Indirizzi:
Royal Childrens Hosp, F Douglas Stephens Surg Res Lab, Parkville, Vic 3052, Australia Royal Childrens Hosp Parkville Vic Australia 3052 le, Vic 3052, Australia
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 3, volume: 166, anno: 2000,
pagine: 249 - 258
SICI:
1422-6405(2000)166:3<249:IVFOHI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; CALCITONIN-GENE; TESTICULAR DESCENT; MESENCHYMAL TRANSFORMATION; GENITOFEMORAL NERVE; PALATAL FUSION; CRYPTORCHIDISM; GUBERNACULUM; RECEPTORS; CELLS;
Keywords:
calcitonin gene-related peptide; inguinal hernia; processus vaginalis; epithelial-mesenchymal transition; cryptorchidism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hasthorpe, S Royal Childrens Hosp, F Douglas Stephens Surg Res Lab, Flemington Rd, Parkville, Vic 3052, Australia Royal Childrens Hosp Flemington Rd Parkville Vic Australia 3052
Citazione:
J.M. Hutson et al., "In vitro fusion of human inguinal hernia with associated epithelial transformation", CELLS T ORG, 166(3), 2000, pp. 249-258

Abstract

The processus vaginalis (PV) is a peritoneal diverticulum which forms to allow descent of the fetal testis to the scrotum. During human development fusion and obliteration of the PV often fails to occur with the result that inguinal hernias are the most prevalent congenital abnormality requiring surgery in childhood. Androgen is proposed to regulate testicular descent viathe genitofemoral nerve which releases the neuropeptide calcitonin gene-related peptide (CGRP). It is possible that subsequent fusion of the PV and tissue remodelling following descent is indirectly controlled by androgen via CGRP action. An organ culture assay was developed to assess fusion of thePV taken from inguinal herniotomy in infants. Fusion was induced in vitro by CGRP but not by CGRP 8-37, CGRP 27-37 or dihydrotestosterone in equimolar concentrations. Fusion was accompanied by transformation of the epithelium, as shown by staining of intermediate filament proteins, cytokeratin and vimentin. Localization studies for CGRP receptors on 25 specimens indicatedCGRP acts on mesenchymal fibroblasts but not directly on PV epithelium suggesting an indirect pathway. Hepatocyte growth factor/scatter factor was found to induce fusion of PV and may be involved as an intermediate molecule in the fusion cascade. This study represents the first approach to understanding the humoral control and underlying mechanism by which the PV fuses. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 11:48:57