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Titolo:
Volume and differentiation of striatal grafts in rats: Relationship to thenumber of cells implanted
Autore:
Watts, C; McNamara, IR; Dunnett, SB;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England Univ Cambridge, Dept Neurosurg, Cambridge CB2 2PY, England Univ CambridgeCambridge England CB2 2PY urg, Cambridge CB2 2PY, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY hol, Cambridge CB2 2PY, England
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 1, volume: 9, anno: 2000,
pagine: 65 - 72
SICI:
0963-6897(200001/02)9:1<65:VADOSG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GANGLIONIC EMINENCE; HUNTINGTONS-DISEASE; PATHOLOGICAL RESEARCH; ANIMAL-MODEL; DONOR STAGE; SURVIVAL; RECOVERY; NEURONS; BRAIN; SUSPENSIONS;
Keywords:
striatal grafts; lateral ganglionic eminence; optimum cell number; graft morphology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Watts, C Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way,Cambridge CB2 2PY, England Univ Cambridge Forvie Site,Robinson WayCambridge England CB2 2PY
Citazione:
C. Watts et al., "Volume and differentiation of striatal grafts in rats: Relationship to thenumber of cells implanted", CELL TRANSP, 9(1), 2000, pp. 65-72

Abstract

A growing body of evidence suggests that graft-mediated functional recovery in animal models of Huntington's disease is influenced by the morphology of the striatal grafts. Various parameters, including embryonic dissection,tissue preparation, and surgical delivery into the brain, have been investigated with the aim of increasing the proportion of the grafts comprising striatum-like tissue. While growing evidence suggests that implants derived from the selective dissection of the lateral ganglionic eminence (LGE) contain more striatal tissue, the relationship between the quantity of LGE tissue implanted and the striatum-like proportion of the resultant grafts has not been formally investigated. In this study the volume of striatum-like tissue within the grafts did not increase in a linear manner with increasing numbers of cells implanted. The proportion of the grafts that comprised thestriatum-like patch compartment or P-zone remained constant after an initial rapid increase as the number of LGE cells implanted was increased. Theseresults have important practical implications in determining the optimum number of LGE cells to implant and hence in the design of any surgical protocol for the clinical application of this technique.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:10:14