Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease
Autore:
Armstrong, RJE; Watts, C; Svendsen, CN; Dunnett, SB; Rosser, AE;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 1, volume: 9, anno: 2000,
pagine: 55 - 64
SICI:
0963-6897(200001/02)9:1<55:SNDAFO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ADULT-RAT BRAIN; IN-VITRO PROPAGATION; LONG-TERM SURVIVAL; HUMAN FETAL BRAIN; STEM-CELLS; PROGENITOR CELLS; STRIATAL GRAFTS; PARKINSONS-DISEASE; FUNCTIONAL RECOVERY;
Keywords:
neural stem cell; EGF; FGF-2; striatal graft;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Armstrong, RJE Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way,Cambridge CB2 2PY, England Univ Cambridge Forvie Site,Robinson Way Cambridge England CB2 2PY
Citazione:
R.J.E. Armstrong et al., "Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease", CELL TRANSP, 9(1), 2000, pp. 55-64

Abstract

Expanded neural precursor cells provide an attractive alternative to primary fetal tissue for cell replacement therapies in neurodegenerative diseases. In this study we transplanted epigenetically propagated human neural precursor cells into a rat model of Huntington's disease. Neural precursors survived transplantation and large numbers differentiated to express neuronalantigens, including some that expressed DARPP-32, indicating a mature striatal phenotype had been adopted. Neuronal fibers from the grafts projected diffusely throughout the host brain, although there was no evidence that outgrowth was specifically target directed. This study supports the contention that propagated human neural precursors may ultimately be of use in therapeutic neural transplantation paradigms for diseases such as Huntington's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:57:56