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Titolo:
Chemotaxis activation of peritoneal murine macrophages induced by the transplantation of free and encapsulated pancreatic rat islets
Autore:
Karsten, V; Tritschler, S; Mandes, K; Belcourt, A; Pinget, M; Kessler, L;
Indirizzi:
ULP, Lab Endocrinol Expt, UPRES 2106, Strasbourg 1, France ULP Strasbourg France 1 ndocrinol Expt, UPRES 2106, Strasbourg 1, France
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 1, volume: 9, anno: 2000,
pagine: 39 - 43
SICI:
0963-6897(200001/02)9:1<39:CAOPMM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTIFICIAL MEMBRANE; CELL; XENOGRAFTS; MICE;
Keywords:
transplantation; pancreatic islets; bioartificial pancreas; macrophages; chemotaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kessler, L Serv Endocrinol & Diabetol, Pavillon Leriche,Pl Hop, F-67091 Strasbourg, France Serv Endocrinol & Diabetol Pavillon Leriche,Pl Hop Strasbourg France F-67091
Citazione:
V. Karsten et al., "Chemotaxis activation of peritoneal murine macrophages induced by the transplantation of free and encapsulated pancreatic rat islets", CELL TRANSP, 9(1), 2000, pp. 39-43

Abstract

The present study concerns the influence of the transplantation of free and encapsulated (AN69 membrane, Hospal) islets on the chemotaxis of peritoneal macrophages. Fifty free or encapsulated rat islets, cultured for 24 h, were transplanted in the peritoneal cavity of mice (n = 12). Three days after transplantation, the chemotaxis of peritoneal murine macrophages was tested towards formyl-methionyl-leucyl-phenylalanine (fMLP) and a culture medium conditioned for 3 days by free rat islets isolated from the same rat donor. In response to fMLP, the chemotactic indexes of macrophages from mice transplanted with free or encapsulated islets were 8.09 +/- 2.10 and 9.45 +/-2.76, respectively. These values were significantly higher than those obtained when macrophages from untreated mice were tested (2.421 +/- 0.23; p < 0.01). In response to culture medium conditioned by free islets, the transplanted encapsulated islets failed to enhance macrophage chemotaxis (2.41 +/- 0.53) compared to transplanted free islets (7.00 +/- 2.63; p < 0.01). Thus, encapsulation decreased the specific chemotactic activity of peritoneal macrophages induced by free islet transplantation, probably by prohibiting the diffusion of chemoattractants.

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Documento generato il 25/11/20 alle ore 04:19:07