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Titolo:
Cyclooxygenase-2, a colorectal cancer nonsteroidal anti-inflammatory drug target, is regulated by c-MYB
Autore:
Ramsay, RG; Friend, A; Vizantios, Y; Freeman, R; Sicurella, C; Hammett, F; Armes, J; Venter, D;
Indirizzi:
Peter MacCallum Canc Inst, Differentiat & Transcript Lab, E Melbourne, Vic8006, Australia Peter MacCallum Canc Inst E Melbourne Vic Australia 8006 c8006, Australia
Titolo Testata:
CANCER RESEARCH
fascicolo: 7, volume: 60, anno: 2000,
pagine: 1805 - 1809
SICI:
0008-5472(20000401)60:7<1805:CACCNA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS; EXPRESSION; APOPTOSIS; BINDING; GENE; OLIGODEOXYNUCLEOTIDES; DIFFERENTIATION; CARCINOMA; PROMOTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ramsay, RG Peter MacCallum Canc Inst, Differentiat & Transcript Lab, Locked Bag 1,A Beckett St, E Melbourne, Vic 8006, Australia Peter MacCallum CancInst Locked Bag 1,A Beckett St E Melbourne Vic Australia 8006
Citazione:
R.G. Ramsay et al., "Cyclooxygenase-2, a colorectal cancer nonsteroidal anti-inflammatory drug target, is regulated by c-MYB", CANCER RES, 60(7), 2000, pp. 1805-1809

Abstract

Cyclooxygenase-a (COX-2) Is an important pharmacological target with greatpromise in the prevention and treatment of colorectal cancer (CRC), The mechanism underlying COX-2 overexpression in CRC is unresolved. On the basis of the coincident high levels of the transcription factor c-MYB and COX-2 in CRC, we hypothesized that c-MYB is a candidate activator of COX-2 transcription. We identified 13 c-Myb binding sites in the human COX-2 promoter, Eight of these sites were moderate to high-affinity DNA binding targets. Promoter studies indicated that c-Myb fan activate COX-2 transcription, whereas dominant-negative Myb mediated repression. These data provide the first rational basis for overexpression of COX-2 in CRC and offer an additional potential target for managing this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:57:47