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Titolo:
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis
Autore:
Arola, OJ; Saraste, A; Pulkki, K; Kallajoki, M; Parvinen, M; Voipio-Pulkki, LM;
Indirizzi:
Turku Univ, Dept Med, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 v, Dept Med, FIN-20521 Turku, Finland Turku Univ, Dept Anat, FIN-20521 Turku, Finland Turku Univ Turku FinlandFIN-20521 , Dept Anat, FIN-20521 Turku, Finland Turku Univ, Dept Clin Chem, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 t Clin Chem, FIN-20521 Turku, Finland Turku Univ, Dept Pathol, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 Dept Pathol, FIN-20521 Turku, Finland
Titolo Testata:
CANCER RESEARCH
fascicolo: 7, volume: 60, anno: 2000,
pagine: 1789 - 1792
SICI:
0008-5472(20000401)60:7<1789:ADCICA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CELLS; HEART; ANTIBIOTICS; ICRF-187;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Voipio-Pulkki, LM Turku Univ, Cent Hosp, Dept Med, POB 52, Turku 20521, Finland Turku Univ POB 52 Turku Finland 20521 ku 20521, Finland
Citazione:
O.J. Arola et al., "Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis", CANCER RES, 60(7), 2000, pp. 1789-1792

Abstract

Despite well-documented cardiotoxic effects, doxorubicin remains a major anticancer agent. To study the role of myocardial apoptosis following doxorubicin administration, male Wistar rats were exposed to 1.25, 2.5, and 5 mg/kg of i.p. doxorubicin and terminated on days 1-7 in groups of five. Doxorubicin caused a significant (P < 0.001) and dose-dependent induction of cardiomyocyte apoptosis at 24-48 h after the injection. Repeated injections of 2.5 mg/kg given every other day resulted in peaks of apoptosis at 24 h after each injection. However, no additive effect of repeated dosing was noted. In histological samples, alterations in the cytoskeletal apparatus with focal loss of contractile elements were seen after a single injection. Myocyte necrosis was absent. Thus, acute doxorubicin-induced cardiotoxicity involves cardiomyocyte apoptosis, a potentially preventable form of myocardial tissue loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:28:26