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Titolo:
Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases witht(16;21)(p11;q22) - Common morphologic characteristics for this type of leukemia
Autore:
Imashuku, S; Hibi, S; Sako, M; Lin, YW; Ikuta, K; Nakata, Y; Mori, T; Iizuka, S; Horibe, K; Tsunematsu, Y;
Indirizzi:
Kyoto Prefectural Univ Med, Childrens Res Hosp, Div Pediat, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Dept Pediat, Kyoto, Japan Kyoto Prefectural Univ Med Kyoto Japan v Med, Dept Pediat, Kyoto, Japan Osaka City Gen Hosp, Div Pediat, Osaka, Japan Osaka City Gen Hosp Osaka Japan City Gen Hosp, Div Pediat, Osaka, Japan Kyoto Univ, Fac Med, Dept Pediat, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 Univ, Fac Med, Dept Pediat, Kyoto 606, Japan Yokohama City Univ, Sch Med, Dept Pediat, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan Keio Univ, Sch Med, Dept Pediat, Tokyo 108, Japan Keio Univ Tokyo Japan 108 o Univ, Sch Med, Dept Pediat, Tokyo 108, Japan Social Insurance Saitama Chue Hosp, Dept Pediat, Urawa, Saitama, Japan Social Insurance Saitama Chue Hosp Urawa Saitama Japan a, Saitama, Japan Natl Sapporo Hosp, Dept Pediat, Sapporo, Hokkaido, Japan Natl Sapporo Hosp Sapporo Hokkaido Japan ediat, Sapporo, Hokkaido, Japan Nagoya Univ, Sch Med, Dept Pediat, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 Dept Pediat, Nagoya, Aichi 466, Japan Natl Childrens Hosp, Div Pediat, Tokyo, Japan Natl Childrens Hosp Tokyo Japan hildrens Hosp, Div Pediat, Tokyo, Japan
Titolo Testata:
CANCER
fascicolo: 8, volume: 88, anno: 2000,
pagine: 1970 - 1975
SICI:
0008-543X(20000415)88:8<1970:HBLBI7>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE NONLYMPHOCYTIC LEUKEMIA; ACUTE MYELOBLASTIC-LEUKEMIA; MALIGNANT HISTIOCYTOSIS; ERYTHROPHAGOCYTOSIS; TRANSLOCATION; REARRANGEMENT; T(16-21); TLS/FUS; CELLS; ANLL;
Keywords:
hemophagocytosis; acute myeloid leukemia; translocation t(16;21)(p11;q22); translocation t(8;16)(p11;p13); TLS/FUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Imashuku, S Kyoto Prefectural Univ Med, Childrens Res Hosp, Div Pediat, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 028566, Japan
Citazione:
S. Imashuku et al., "Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases witht(16;21)(p11;q22) - Common morphologic characteristics for this type of leukemia", CANCER, 88(8), 2000, pp. 1970-1975

Abstract

BACKGROUND. In a previous study of a case of acute megakaryoblastic leukemia with t(16;21)(p11;q22), which displayed hemophagocytosis by leukemic blasts, the authors mentioned that the same type of morphology had been cited in the literature for 4 other cases of acute myeloid leukemia (AML) with the same translocation. This observation prompted the authors to examine morecases of AML with t(16;21)(p11;q22) for this morphology. METHODS. The authors reviewed bone marrow smears for the presence of hemophagocytosis in 7 patients with AML identified as having t(16;21)(p11;q22). RESULTS. The leukemias belonged to the FAB-M1/M7 (n = 5), M5b (n = 2), andcontained phagocytic blasts in various percentages (< 0.2-36.7%). The blasts contained either single or multiple cytoplasmic vacuoles, in some of which the phagosomes were visible. The engulfed hemopoietic cells (red cells, erythroblasts, lymphocytes, and thrombocytes) were also noted in their cytoplasm. These observations confirmed that hemophagocytosis by leukemic blasts is a common and characteristic feature of this type of leukemia. CONCLUSIONS. The study of 12 cases (the 7 cases described here and the previous 5 cases) strongly supports the hypothesis that hemophagocytosis by leukemic blasts is common and characteristic in this type of leukemia, which may he related to the specific chromosome aberration of t(16;21)(p11;q22). Cancer 2000;88: 1970-5. (C) 2000 American Cancer Society.

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Documento generato il 23/01/20 alle ore 03:56:48