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Titolo:
Sensitivity of repeated interdigital web pinching to detect antinociceptive effects of ibuprofen
Autore:
Growcott, JW; Stone, A; Beise, R; Stammer, H; Tetzloff, W; DeMey, C;
Indirizzi:
Zeneca Pharmaceut, Med Res & Commun Grp, Clin Pharmacol Unit, MacclesfieldSK10 4TG, Cheshire, England Zeneca Pharmaceut Macclesfield Cheshire England SK10 4TG heshire, England IPHAR Inst Clin Pharmacol, D-85635 Hohenkirchen Siegertsbru, Germany IPHARInst Clin Pharmacol Hohenkirchen Siegertsbru Germany D-85635 rmany
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 4, volume: 49, anno: 2000,
pagine: 331 - 336
SICI:
0306-5251(200004)49:4<331:SORIWP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS HYPERALGESIA; PAIN; STIMULATION; MECHANISMS; RAT;
Keywords:
ibuprofen; interdigital web pinching; pain; volunteers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Growcott, JW Zeneca Pharmaceut, Med Res & Commun Grp, Clin Pharmacol Unit,MacclesfieldSK10 4TG, Cheshire, England Zeneca Pharmaceut Macclesfield Cheshire England SK10 4TG and
Citazione:
J.W. Growcott et al., "Sensitivity of repeated interdigital web pinching to detect antinociceptive effects of ibuprofen", BR J CL PH, 49(4), 2000, pp. 331-336

Abstract

Aims The aim of the current study was to assess the viability of the interdigital web pinch model as a test for analgesic activity in volunteer-basedearly phase drug development. Methods Pain thresholds and sensitization to a series of four sessions of interdigital web pinching (12 Newtons force) were measured in 26 male volunteers before and 1 and 3 h after oral dosing with ibuprofen (800 mg) or placebo to ibuprofen. Within each time point, the pain thresholds were measured by calculating the average visual analogue scores (VAS) for the first session of pinching (VAS-1). Sensitization to pinching was assessed by calculating the average changes in these scores for the three subsequent sessions of pinching (VAS-2). Moreover, the difference between the VAS score after the first session of pinching and that obtained at the end of the fourth session of pinching was calculated as a secondary endpoint (VAS-3). Results Treatment with ibuprofen had no significant effect on VAS-1 at either 1 or 3 h after dosing. However, the mean values of VAS-2 and VAS-3, were significantly reduced (P < 0.05) following treatment with ibuprofen. Conclusions This model has been able to detect an antinociceptive effect with ibuprofen. However, large numbers of subjects were required in order todemonstrate this effect and this feature would restrict the model's utility in early phase clinical trials where small numbers of subjects are normally employed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:50:30