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Titolo:
Hematological recovery and peripheral blood progenitor cell mobilization after induction chemotherapy and GM-CSF plus G-CSF in breast cancer
Autore:
Charrier, S; Chollet, P; Bay, JO; Cure, H; Kwiatkowski, F; Portefaix, G; Communal, Y; Betail, G; Plagne, R; Chassagne, J;
Indirizzi:
Ctr Lutte Contre Canc Jean Perrin, Immunol Lab, F-63011 Clermont Ferrand 1, France Ctr Lutte Contre Canc Jean Perrin Clermont Ferrand France 1 nd 1, France Fac Med & Pharm, Immunol Lab, Clermont Ferrand, France Fac Med & Pharm Clermont Ferrand France l Lab, Clermont Ferrand, France
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 7, volume: 25, anno: 2000,
pagine: 705 - 710
SICI:
0268-3369(200004)25:7<705:HRAPBP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HIGH-DOSE CHEMOTHERAPY; HEMATOPOIETIC STEM-CELLS; BONE-MARROW; SUPPORT; TRANSPLANTATION;
Keywords:
GM-CSF plus G-CSF; hematological recovery; PBPC mobilization; breast cancer; TNCF chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Charrier, S Ctr Lutte Contre Canc Jean Perrin, Immunol Lab, 58 Rue Montalembert,BP 392, F-63011 Clermont Ferrand 1, France Ctr Lutte Contre Canc JeanPerrin 58 Rue Montalembert,BP 392 Clermont Ferrand France 1
Citazione:
S. Charrier et al., "Hematological recovery and peripheral blood progenitor cell mobilization after induction chemotherapy and GM-CSF plus G-CSF in breast cancer", BONE MAR TR, 25(7), 2000, pp. 705-710

Abstract

In order to determine the effect of GM-CSF plus G-CSF in combination in breast cancer patients receiving an effective induction regimen, we compared hematological recovery and peripheral blood progenitor cell (PBPC) mobilization according to colony-stimulating factor (CSF) support, Forty-three breast cancer patients were treated by TNCF (THP-doxorubicin, vinorelbine, cyclophosphamide, fluorouracil, D1 to D4) with CSF support: 11 patients received GM-CSF (D5 to D14); 16 patients G-CSF (D5 to D14) and 16 patients GM-CSF (D5-D14) plus G-CSF (D10-D14). Between two subsequent cycles, progenitor cells were assessed daily, from D13 to D17, The WBC count was similar for patients receiving G-CSF alone or GM-CSF plus G-CSF, but significantly greaterthan that of patients receiving GM-CSF alone (P < 0.001). The GM-CSF plus G-CSF combination led to better PBPC mobilization, with significantly different kinetics (P < 0.001) and optimal mean values of CFU-GM, CD34(+) cells and cells in cycle, at D15 compared to those obtained with G-CSF or GM-CSF alone, The significantly greater PBPC mobilization obtained with a CSF combination by D15 could be of value for PBPC collection and therapeutic reinjection after high-dose chemotherapies.

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Documento generato il 27/11/20 alle ore 04:13:28