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Titolo:
Use of placebo control groups in evaluating efficacy of treatment of unipolar major depression
Autore:
Schatzberg, AF; Kraemer, HC;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 47, anno: 2000,
pagine: 736 - 744
SICI:
0006-3223(20000415)47:8<736:UOPCGI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRUE DRUG RESPONSE; PATTERN-ANALYSIS; RECURRENT DEPRESSION; SURVIVAL ANALYSIS; CONTROLLED TRIAL; PREDICTORS; RELAPSE; AMITRIPTYLINE; SERTRALINE; PREVENTION;
Keywords:
major depression; randomized controlled trial; placebo; antidepressants; outcomes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schatzberg, AF Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 401 Quarry Rd, Stanford, CA 94305 USA Stanford Univ 401 Quarry Rd Stanford CA USA 94305 94305 USA
Citazione:
A.F. Schatzberg e H.C. Kraemer, "Use of placebo control groups in evaluating efficacy of treatment of unipolar major depression", BIOL PSYCHI, 47(8), 2000, pp. 736-744

Abstract

Double-blind, random-assignment placebo-controlled trials are routinely used in evaluating efficacy of potential antidepressant agents. In recent years concern has risen that placebo response rates in unipolar depression aretoo high, and this has eroded confidence in both old and new agents At thesame time, the use of placebos has been questioned by patients and their advocates, We review factors that have been commonly explored as associated with placebo response (e.g., length of episode, severity, subtype), as wellas issues in methodology (e.g., interrater reliability, statistical artifacts). We discuss possible methods of dealing with the problem of placebo response, emphasizing reconceptualizing effect sizes to design more powerful single trials and a systematic sequence of trials to achieve the right answers. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:12:02