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Titolo:
Expression of retinoid receptors during human monocyte differentiation in vitro
Autore:
Fritsche, J; Stonehouse, TJ; Katz, DR; Andreesen, R; Kreutz, M;
Indirizzi:
Univ Regensburg, Dept Hematol & Oncol, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany Univ Coll London, Dept Immunol, Sch Med, London W1P 6DB, England Univ CollLondon London England W1P 6DB Sch Med, London W1P 6DB, England
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 270, anno: 2000,
pagine: 17 - 22
SICI:
0006-291X(20000402)270:1<17:EORRDH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-BINDING PROTEIN; CELL LINE HL-60; X-RECEPTOR; DENDRITIC CELLS; NUCLEAR RECEPTOR; THYROID-HORMONE; BLOOD MONOCYTES; MESSENGER-RNA; ALL-TRANS; RXR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kreutz, M Univ Regensburg, Dept Hematol & Oncol, Franz Josef Str Allee 11,D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93042
Citazione:
J. Fritsche et al., "Expression of retinoid receptors during human monocyte differentiation in vitro", BIOC BIOP R, 270(1), 2000, pp. 17-22

Abstract

1 alpha,25-Dihydroxyvitamin D-3 (1,25(OH)(2)VD3) and retinoic acid (RA) modulate the activation of monocytes (MO) and their differentiation into macrophages (MAC). As these effects are mostly mediated by heterodimers or homodimers of the specific nuclear receptors for 1,25(OH)(2)VD3 and RA, we investigated the expression of the retinoic acid receptors (RAR) alpha, beta, and gamma and the retinoid X-receptor (RXR) a in MO during differentiation into MAC or dendritic cells (DC). The mRNA of all investigated receptors except RAR beta was detected in short-term cultured MO. During differentiationof MO to MAC the mRNA expression of the RA receptors decreased. In contrast, along the differentiation pathway of MO to DC, only the mRNA expression of RAR gamma declined, whereas RAR alpha and RXR alpha were constantly expressed at a high level. Despite the strong expression of RAR alpha and RXR alpha at mRNA level in MO-derived DC, the protein expression of the receptors was low in these cells. However, MO and MO-derived MAC showed a strong expression of these receptors at protein level. This suggests that a posttranscriptional or posttranslational mechanism of receptor regulation is occurring in these cells, and in particular in the DC. The inverse regulation of RA receptor expression and protein levels between MAC and DC may control the responsiveness of these cells to 1,25(OH)(2)VD3 and RA. (C) 2000 AcademicPress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:10:09