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Titolo:
Effects of N-methyl-D-aspartate receptor antagonists on reinstatement of cocaine-seeking behavior by priming injections of cocaine or exposures to cocaine-associated cues in rats
Autore:
Bespalov, AY; Zvartau, EE; Balster, RL; Beardsley, PM;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Pavlov Med Univ, Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia Pavlov Med Univ St Petersburg Russia 197089 St Petersburg 197089, Russia
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 1, volume: 11, anno: 2000,
pagine: 37 - 44
SICI:
0955-8810(200002)11:1<37:EONRAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; DISCRIMINATIVE STIMULUS PROPERTIES; PRECIPITATED OPIOID WITHDRAWAL; SELF-ADMINISTRATION BEHAVIOR; BRAIN-STIMULATION REWARD; NUCLEUS-ACCUMBENS; NMDA ANTAGONIST; MK-801; MORPHINE; DRUG;
Keywords:
cocaine; self-administration; reinstatement; D-CPPene (SDZ EAA 494); memantine; context; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Beardsley, PM Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, POB 980613, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980613 Richmond VA USA 23298
Citazione:
A.Y. Bespalov et al., "Effects of N-methyl-D-aspartate receptor antagonists on reinstatement of cocaine-seeking behavior by priming injections of cocaine or exposures to cocaine-associated cues in rats", BEHAV PHARM, 11(1), 2000, pp. 37-44

Abstract

The reinstatement of extinguished cocaine self-administration behavior wasstudied in rats pretreated with N-methyl-D-aspartate receptor antagonists. Rats were trained to self-administer intravenous cocaine (0.32 mg/kg/infusion) during five consecutive daily sessions that were followed by five consecutive daily extinction sessions, during which cocaine was unavailable andcocaine-associated cues (sound and light) were absent. Neither the competitive N-methyl-D-aspartate receptor antagonist D-CPPene (0.3-3 mg/kg) nor the low-affinity N-methyl-D-aspartate receptor channel blocker memantine (1-10 mg/kg) reinstated extinguished responding. Priming injections of intravenous cocaine (Experiment 1), and exposures to cocaine-associated stimuli (buzzer and light; Experiment 2) engendered responding on the reinforced leverin excess of that on the non-reinforced lever. In Experiment 1, administration of D-CPPene or memantine prior to the priming injection of cocaine eliminated the difference between reinforced-lever and non-reinforced-lever response rates. For both D-CPPene and memantine, however, this effect was largely due to increased responding upon the non-reinforced lever rather than to decreased reinforced-lever responding. In Experiment 2, D-CPPene, but not memantine, abolished in a dose-dependent manner the selective increase inreinforced-lever over non-reinforced-lever responding that was induced by exposures to cocaine-related stimuli. This effect of D-CPPene was not due to increased non-reinforced-lever responding. These data help define the boundaries within which N-methyl-D-aspartate receptor antagonists can prevent reinstatement of cocaine-seeking behavior (e.g. type of antagonist used andreinstatement procedure). (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 06:26:35