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Titolo:
Differential effects of long-term renin-angiotensin system blockade on limitation of infarct size in cholesterol-fed rabbits
Autore:
Hoshida, S; Yamashita, N; Kuzuya, T; Hori, M;
Indirizzi:
Osaka Univ, Sch Med, Dept Med 1, Div Cardiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Cardiol, Suita, Osaka 5650871, Japan Osaka Rosai Hosp, Div Cardiovasc, Sakai, Osaka 5918025, Japan Osaka Rosai Hosp Sakai Osaka Japan 5918025 c, Sakai, Osaka 5918025, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 149, anno: 2000,
pagine: 287 - 294
SICI:
0021-9150(200004)149:2<287:DEOLRS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CONVERTING ENZYME-INHIBITOR; EXPERIMENTAL HEART-FAILURE; SMOOTH-MUSCLE CELLS; NITRIC-OXIDE DONOR; BRADYKININ ANTAGONIST; GENE-EXPRESSION; ACE-INHIBITORS; ISCHEMIA; DOGS;
Keywords:
angiotensin-converting enzyme; angiotensin II receptor antagonist; atherosclerosis; bradykinin; endothelium-dependent relaxation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hoshida, S Osaka Univ, Sch Med, Dept Med 1, Div Cardiol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
S. Hoshida et al., "Differential effects of long-term renin-angiotensin system blockade on limitation of infarct size in cholesterol-fed rabbits", ATHEROSCLER, 149(2), 2000, pp. 287-294

Abstract

We evaluated the effects of chronic inhibition of angiotensin-converting enzyme (ACE) or receptor blockade of angiotensin II type I on the size of myocardial infarcts induced by coronary occlusion-reperfusion in rabbits fed a high-cholesterol or normal diet for 10 weeks. In treated rabbits, myocardial infarction occurred 24 h after the last dose of enalapril or L-158809, an angiotensin II type I receptor antagonist, because of the drugs' waning effects on hemodynamic parameters. The size of the infarct was significantly larger in cholesterol-fed rabbits than in rabbits fed a normal diet. Thisaugmentation of infarct size in cholesterol-fed rabbits was reversed by long-term treatment with enalapril, but not L-158809. The favorable effects of enalapril treatment disappeared after pretreatment with the bradykinin B-2 receptor blocker HOE 140. Long-term enalapril or L-158809 administration did not reduce the size of the infarct in rabbits fed a normal diet. ACE activity in ischemic myocardium significantly exceeded that in nonischemic myocardium and was further increased in cholesterol-fed rabbits, but was significantly reduced by long-term enalapril, but not L-158809. Moreover, treatment with enalapril, but not L-158809, restored acetylcholine-induced endothelium-dependent relaxation of aortic rings from cholesterol-fed rabbits. These results demonstrate that long-term ACE inhibition, but not angiotensinII type I receptor blockade, effectively reduces the size of myocardial infarcts in cholesterol-fed rabbits. The favorable effects of enalapril treatment may involve primarily a bradykinin B-2 receptor-mediated pathway. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:01:45