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Titolo:
Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis - Evidence of free radical-mediated injury
Autore:
Solans, R; Motta, C; Sola, R; La Ville, AE; Lima, J; Simeon, P; Montella, N; Armadans-Gil, L; Fonollosa, V; Vilardell, M;
Indirizzi:
Hosp Gen Univ Vall Hebron, Planta Pares 3, Barcelona 08035, Spain Hosp GenUniv Vall Hebron Barcelona Spain 08035 , Barcelona 08035, Spain Hotel Dieu, Clermont Ferrand, France Hotel Dieu Clermont Ferrand FranceHotel Dieu, Clermont Ferrand, France St Joan Univ, Gen Hosp, Reus, Spain St Joan Univ Reus SpainSt Joan Univ, Gen Hosp, Reus, Spain
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 4, volume: 43, anno: 2000,
pagine: 894 - 900
SICI:
0004-3591(200004)43:4<894:AOEMFL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-CELL DEFORMABILITY; OXYGEN FREE-RADICALS; RAYNAUDS-PHENOMENON; SCLERODERMA; DISEASES; BLOOD; LIPOPROTEINS; PATHOGENESIS; ADHERENCE; OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Solans, R Hosp Gen Univ Vall Hebron, Planta Pares 3, P Vall Hebron 119-129, Barcelona 08035, Spain Hosp Gen Univ Vall Hebron P Vall Hebron 119-129 Barcelona Spain 08035
Citazione:
R. Solans et al., "Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis - Evidence of free radical-mediated injury", ARTH RHEUM, 43(4), 2000, pp. 894-900

Abstract

Objective. To elucidate whether oxidative injury occurs in systemic sclerosis (SSc) and whether it affects the erythrocyte membrane (EM) properties,Methods. EM fluidity and lipid composition (cholesterol:phospholipid molarratio [C:PL], fatty acid composition) were studied in 52 patients with SScand in 53 subjects without SSc (32 with primary Raynaud's phenomenon [RP] and 21 healthy subjects [controls]), Fluidity was measured as the fluorescence anisotropy of the hydrophobic fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene). Lipid peroxidation products were determined as thiobarbituricacid-reactive substances (TBARS). Results. EM fluidity was significantly lower in SSc patients than in primary RP patients and controls (P < 0.001). The EM C:PL molar ratio was significantly higher in SSc patients than in primary RP patients and controls (P < 0.05). Levels of EM polyunsaturated n6 fatty acids (PUFA n6) mere significantly lower in SSc patients than in primary RP patients and controls (P < 0.001). TBARS were significantly increased in SSc patients compared with primary RP patients and controls (P < 0.001). Multiple regression analyses indicated that the reduced EM fluidity was partly due to its greater C:PL molar ratio, lower PUFA n6 content, and higher TBARS levels, EM fluidity was Power among patients with nailfold capillary loss (P < 0.001) and digital ischemic ulcers (P < 0.05). EM lipid peroxidation products were higher among patients with pulmonary involvement (bibasal pulmonary fibrosis [P < 0.05] and reduced levels of diffusing capacity for carbon monoxide [P < 0.001]) and among patients who were positive for anti-topoisomerase I antibodies (P < 0.05) or negative for anticentromere antibodies (P < 0.001). Conclusion. Our findings support the idea that oxidative injury occurs in SSc and that, through lipid peroxidation, it induces structural, and functional changes of the EM that may contribute to the development of the microvascular abnormalities that are seen in the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:14:51