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Titolo:
Expression of macrophage (M phi) scavenger receptor, CD36, in cultured human aortic smooth muscle cells in association with expression of peroxisome proliferator activated receptor-gamma, which regulates gain of M phi-like phenotype in vitro, and its implication in atherogenesis
Autore:
Matsumoto, K; Hirano, K; Nozaki, S; Takamoto, A; Nishida, M; Nakagawa-Toyama, Y; Janabi, MY; Ohya, T; Yamashita, S; Matsuzawa, Y;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Mol Sci, Suita, Osaka 5650871, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 4, volume: 20, anno: 2000,
pagine: 1027 - 1032
SICI:
1079-5642(200004)20:4<1027:EOM(PS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MONOCYTE-DERIVED MACROPHAGES; OXIDIZED LDL; PPAR-GAMMA; INTERFERON-GAMMA; GLYCOPROTEIN-IV; DEFICIENCY; SUPPRESSION; LEADS;
Keywords:
CD36; foam cells; oxidized LDL; peroxisome proliferator activated receptor-gamma; scavenger receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, K Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
K. Matsumoto et al., "Expression of macrophage (M phi) scavenger receptor, CD36, in cultured human aortic smooth muscle cells in association with expression of peroxisome proliferator activated receptor-gamma, which regulates gain of M phi-like phenotype in vitro, and its implication in atherogenesis", ART THROM V, 20(4), 2000, pp. 1027-1032

Abstract

CD36 is one of the major receptors for oxidized low density lipoproteins belonging to macrophage (M phi) scavenger receptor (SR) class B and is thought to play an important role in the foam cell formation from monocyte-M phiin the atherosclerotic lesions. Although it has been hypothesized that smooth muscle cells (SMCs) may be the other origin of foam cells in vivo, supporting data are still very limited. In the present study, we have tested the expression of a variety of SRs, including CD36, in 8 lots of primary human aortic SMCs (HASMCs) explanted from 8 different donors. Functional CD36 was expressed in cultured HASMCs, and the levels of expression were widely ranged between the lots. SR class A (SR-A) was expressed abundantly in CD36-negative lots. Other M phi markers, such as CD32 and CD68, were expressed in all lots tested. These data suggest that the cultured HASMCs gained an M phi-like phenotype. To determine the mechanism for the above-described phenotypic change, we have tested the expression of a nuclear receptor, peroxisome proliferator activated receptor-gamma, in those cells. This nuclear receptor was abundantly expressed in CD36-positive lots, whereas c-fms was expressed abundantly in CD36-negative/SR-A-positive lots. The synthetic ligandof peroxisome proliferator activated receptor-gamma, troglitazone, upregulated the expression of CD36 only in CD36-positive lots.-These observations demonstrate that cultured HASMCs can gain an M phi-like phenotype, possiblyclassified by the expression of CD36 or SR-A. The present study may support the possibilities of transformation of HASMCs into foam cells in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:32:16