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Titolo:
MULTIPLE IMMUNOREACTIVE INHIBIN PROTEINS IN SERUM FROM POSTMENOPAUSALWOMEN WITH EPITHELIAL OVARIAN-CANCER
Autore:
LAMBERTMESSERLIAN GM; STEINHOFF M; ZHENG W; CANICK JA; GAJEWSKI WH; SEIFER DB; SCHNEYER AL;
Indirizzi:
BROWN UNIV,WOMEN & INFANTS HOSP,DEPT PATHOL & LAB MED PROVIDENCE RI 02905 BROWN UNIV,WOMEN & INFANTS HOSP,DEPT OBSTET & GYNECOL PROVIDENCE RI 02905 OHIO STATE UNIV,MED CTR,DEPT OBSTET & GYNECOL COLUMBUS OH 43210 MASSACHUSETTS GEN HOSP,DEPT MED,REPROD ENDOCRINE UNIT,NATL CTR INFERTIL RES BOSTON MA 02114
Titolo Testata:
Gynecologic oncology
fascicolo: 3, volume: 65, anno: 1997,
pagine: 512 - 516
SICI:
0090-8258(1997)65:3<512:MIIPIS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; HUMAN FOLLICULAR-FLUID; ALPHA-INHIBIN; PRECURSOR PROTEINS; MARKER; RADIOIMMUNOASSAY; SUBUNIT; CA-125; BOVINE; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Lambertmesserlian et al., "MULTIPLE IMMUNOREACTIVE INHIBIN PROTEINS IN SERUM FROM POSTMENOPAUSALWOMEN WITH EPITHELIAL OVARIAN-CANCER", Gynecologic oncology, 65(3), 1997, pp. 512-516

Abstract

Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and alpha inhibin precursors (pro-alpha C), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-alpha C inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-alpha C) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro-alpha C, with 22% of women with EOC having levels that exceeded the rangeof values in women without EOC. Since CA 125 and pro-alpha C levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that alpha inhibin secretion, especially pro-alpha C, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:42:15