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Titolo:
INTRAPERITONEAL CARBOPLATIN WITH OR WITHOUT INTERFERON-ALPHA IN ADVANCED OVARIAN-CANCER PATIENTS WITH MINIMAL RESIDUAL DISEASE AT 2ND LOOK - A PROSPECTIVE RANDOMIZED TRIAL OF 111 PATIENTS
Autore:
BRUZZONE M; RUBAGOTTI A; GADDUCCI A; CATSAFADOS E; FOGLIA G; BRUNETTI I; GIANNESSI PG; CARNINO F; ISKRA L; ROSSO R; MARTONI A; PANNUTI F; DELISI V; MALTONI R; RIDOLFI R; MAMMOLITI S; GALLO L; BOCCARDO F; RAGNI N; CONTE PF;
Titolo Testata:
Gynecologic oncology
fascicolo: 3, volume: 65, anno: 1997,
pagine: 499 - 505
SICI:
0090-8258(1997)65:3<499:ICWOWI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND-LOOK LAPAROTOMY; PHASE-II; CHEMOTHERAPY; CISPLATIN; MANAGEMENT; CARCINOMA; THERAPY; RADIOTHERAPY; MELPHALAN; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Bruzzone et al., "INTRAPERITONEAL CARBOPLATIN WITH OR WITHOUT INTERFERON-ALPHA IN ADVANCED OVARIAN-CANCER PATIENTS WITH MINIMAL RESIDUAL DISEASE AT 2ND LOOK - A PROSPECTIVE RANDOMIZED TRIAL OF 111 PATIENTS", Gynecologic oncology, 65(3), 1997, pp. 499-505

Abstract

From June 1990 to October 1994, 111 advanced ovarian cancer patients with minimal (less than 2 cm) residual disease after platinum-based front-line chemotherapy and second-look laparotomy entered a cooperativerandomized study aimed at evaluating the effectiveness and the toxicity of the addition of interferon-alpha 2 to carboplatin, both intraperitoneally (ip) administered. Patients were randomized to receive either 3 courses of ip Carboplatin 400 mg/m(2) Day 1 q 28 days (54 pts) (CBDCA) or ip interferon-alpha 25 x 10(6) U Day 1 + ip carboplatin 400 mg/m(2) Day 2 q 28 days (57 pts) (CBDCA + IFN). Patients treated with interferon experienced more severe (WHO grade 3-4) leukopenia (28% vs 17.1%) and anemia (14% vs 4.2%). Fever (P = 0.000) and flu-like syndrome(P = 0.02) were significantly more frequent in the combination arm. No difference in gastroenteric, neurologic, or renal toxicity was observed. At a median follow-up time of 13 months (range 1-72) 71 patients showed a disease progression (31 CBDCA, 40 CBDCA + IFN) and 44 patients died (21 CBDCA, 23 CBDCA + IFN). Median progression-free survival was 11 months in the CBDCA group and 10 months in the CBDCA + IFN arm. Median survival was 22 and 29 months in CBDCA and CBDCA + IFN arm, respectively. In conclusion, intraperitoneal interferon-alpha does not seem to improve the results achievable with intraperitoneal carboplatin in this subset of patients, while the toxicity and the costs of the combination are consistently higher than with chemotherapy alone. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:45:48