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Titolo:
EFFECTS OF BETA-CAROTENE AND OTHER FACTORS ON OUTCOME OF CERVICAL DYSPLASIA AND HUMAN PAPILLOMAVIRUS INFECTION
Autore:
ROMNEY SL; HO GYF; PALAN PR; BASU J; KADISH AS; KLEIN S; MIKHAIL M; HAGAN RJ; CHANG CJ; BURK RD;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461
Titolo Testata:
Gynecologic oncology
fascicolo: 3, volume: 65, anno: 1997,
pagine: 483 - 492
SICI:
0090-8258(1997)65:3<483:EOBAOF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM FOLLOW-UP; INTRAEPITHELIAL NEOPLASIA; NATURAL-HISTORY; NUTRIENT STATUS; CANCER; RISK; DIETARY; PLASMA; WOMEN; INDICATORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Romney et al., "EFFECTS OF BETA-CAROTENE AND OTHER FACTORS ON OUTCOME OF CERVICAL DYSPLASIA AND HUMAN PAPILLOMAVIRUS INFECTION", Gynecologic oncology, 65(3), 1997, pp. 483-492

Abstract

Women with histopathologically confirmed cervical intraepithelial neoplasia (GIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of GIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papillomavirus (HPV) detection were obtained at each visit, and an endpoint biopsy was performed at 9 months. Sixty-nine subjects had a biopsy endpoint evaluation; 9 of 39 (23%) subjects in the beta-carotene group versus 14 of 30 (47%) in the placebo group had regression of CIN (P = 0.039). Independent risk factors for persistent CIN at 9 months included type-specific persistent HPV infection (OR = 11.38, P = 0.006) and continual HPV infection with ahigh viral load (OR = 14.25, P = 0.007) at baseline and 9 months, an initial diagnosis of greater than or equal to CIN II (OR = 6.74, P = 0.016), and older age (OR for greater than or equal to 25 years = 4.10,P = 0.072). After controlling for these factors, the beta-carotene and placebo groups did not differ in risk for having CIN at 9 months (OR= 1.53, P = 0.550). Resolution of baseline HPV infection was significantly correlated with non-high-risk HPV types (RR = 2.94, P = 0.015), age <25 years (RR = 2.62, P = 0.014), and douching after sexual intercourse (RR = 3.02, P = 0.012), but not with randomization group. Our data indicate that a large proportion of mild CIN lesions regress; age and HPV infection play an important role in the natural course of CIN; and repeated HPV testing may have a value in distinguishing women who need aggressive treatment for CIN versus those who do not. Supplementation of beta-carotene does not appear to have a detectable benefit in treatment of GIN. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:08:00