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Titolo:
Postglomerular vasoconstriction induced by dopamine D-3 receptor activation in anesthetized rats
Autore:
Luippold, G; Schneider, S; Vallon, V; Osswald, H; Muhlbauer, B;
Indirizzi:
Univ Tubingen, Dept Pharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 4, volume: 278, anno: 2000,
pagine: F570 - F575
SICI:
0363-6127(200004)278:4<F570:PVIBDD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-FUNCTION; KIDNEY; EXPRESSION; CLONING;
Keywords:
R(+)-7-hydroxy-dipropylaminotetraline; 5,6-dimethoxy-2-(di-n-propylamino)indane; S(-)-sulpiride; micropuncture experiments; renal hemodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Luippold, G Univ Tubingen, Dept Pharmacol, Wilhelmstr 561, D-72074 Tubingen, Germany Univ Tubingen Wilhelmstr 561 Tubingen Germany D-72074 Germany
Citazione:
G. Luippold et al., "Postglomerular vasoconstriction induced by dopamine D-3 receptor activation in anesthetized rats", AM J P-REN, 278(4), 2000, pp. F570-F575

Abstract

In the present study we investigated the renal hemodynamic effects of dopamine Ds receptor activation by R(+)-7-hydroxy-dipropylaminotetraline (7-OH-DPAT) in thiopental-anesthetized Sprague-Dau ley rats. In clearance experiments infusion of 7-OH-DPAT (0.01-1.0 mu g kg(-1) min(-1)) dose-dependently elevated glomerular filtration rate (GFR) without affecting mean arterial blood pressure (MAP). In renal blood dow experiments 7-OH-DPAT, infusion 1.0pg kg-l min(-1) increased GFR by 16 +/- 2%, associated with an unexpected fall in renal blood fl by 20 + 3% and a significant elevation of renal vascular resistance by 18 + 3%. The renal hemodynamic changes were not influenced by pretreatment with the D-2-receptor antagonist S(-)sulpiride hut were completely abolished during D-3 receptor inhibition by 5,6-dimethoxy-2-(di-n-propylamino)indane (U-99194A). In micropuncture experiments 7-OH-DPAT (1.0 pg kg(-1)-min(-1)) significantly elevated stop-flow pressure measured in the early proximal tubules and reduced hydrostatic pressure at the first branching point of the efferent arteriole without altering MAP. We conclude from these data that pharmacological activation of dopamine D-3 receptors affects renal hemodynamics in anesthetized rats by preferential postglomerular vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:25:39