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Titolo:
Dietary coenzyme Q(10) supplement renders swine hearts resistant to ischemia-reperfusion injury
Autore:
Maulik, N; Yoshida, T; Engelman, RM; Bagchi, D; Otani, H; Das, DK;
Indirizzi:
Univ Connecticut, Sch Med, Dept Surg, Div Cardiovasc, Farmington, CT 06030USA Univ Connecticut Farmington CT USA 06030 diovasc, Farmington, CT 06030USA Baystate Med Ctr, Dept Surg, Springfield, MA 01199 USA Baystate Med Ctr Springfield MA USA 01199 Surg, Springfield, MA 01199 USA Creighton Univ, Sch Pharm & Allied Hlth Profess, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 llied Hlth Profess, Omaha, NE 68178 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 278, anno: 2000,
pagine: H1084 - H1090
SICI:
0363-6135(200004)278:4<H1084:DCQSRS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ANTIOXIDANT RESERVE; PROTEIN-DEGRADATION; LIPID-PEROXIDATION; UBIQUITIN SYSTEM; MAMMALIAN-CELLS; FREE-RADICALS; RAT-HEART; MALONALDEHYDE;
Keywords:
ubiquitin; ubiquinone; oxygen free radicals; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Das, DK Univ Connecticut, Sch Med, Dept Surg, Div Cardiovasc, 263 Farmington Ave, Farmington, CT 06030 USA Univ Connecticut 263 Farmington Ave Farmington CT USA 06030 30 USA
Citazione:
N. Maulik et al., "Dietary coenzyme Q(10) supplement renders swine hearts resistant to ischemia-reperfusion injury", AM J P-HEAR, 278(4), 2000, pp. H1084-H1090

Abstract

To examine whether nutritional supplementation of coenzyme Q(10) (CoQ(10))can reduce myocardial ischemia-reperfusion injury, a group of swine was fed a regular diet supplemented with CoQ(10) (5 mg kg(-1).day(-1)) for 30 days. Another group of pigs that were fed a regular diet supplemented with placebo served as a control. After 30 days, isolated in situ pig hearts were prepared and hearts were perfused with a cardiopulmonary pump system. Each heart was subjected to 15 min of regional ischemia by snaring of the left anterior descending coronary artery, followed by 60 min of hypothermic cardioplegic global ischemia and 120 min of reperfusion. After the experiments were completed, myocardial infarct size was measured by triphenyltrazolium chloride staining methods. Postischemic left ventricular contractile functionwas better recovered in the CoQ(10) group than in the control group of pigs. CoQ(10)-fed pigs revealed less myocardial infarction and less creatine kinase release from the coronary effluent compared with control pigs. The experimental group also demonstrated a smaller amount of malonaldehyde in thecoronary effluent and a higher content of the endogenous antioxidants ascorbate and thiol. Significant induction of the expression of ubiquitin mRNA was also found in the hearts of the CoQ(10)-fed group. The results of this study demonstrate that nutritional supplementation of CoQ(10) renders the hearts resistant to ischemia-reperfusion injury, probably by reducing the oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:01:42