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Titolo:
Upregulation of HGF activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa
Autore:
Itoh, H; Kataoka, H; Tomita, M; Hamasuna, R; Nawa, Y; Kitamura, N; Koono, M;
Indirizzi:
Miyazaki Med Coll, Dept Pathol 2, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan Miyazaki Med Coll, Dept Surg 2, Kiyotake, Miyazaki 8891692, Japan MiyazakiMed Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan Miyazaki Med Coll, Dept Parasitol, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan Tokyo Inst Technol, Fac Biosci & Biotechnol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan Tokyo Inst Technol Yokohama Kanagawa Japan 2268501 anagawa 2268501, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 4, volume: 278, anno: 2000,
pagine: G635 - G643
SICI:
0193-1857(200004)278:4<G635:UOHAIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE GROWTH-FACTOR; DENSITY-LIPOPROTEIN-RECEPTOR; SERINE-PROTEASE INHIBITOR; PLACENTAL BIKUNIN; MOLECULAR-CLONING; KUNITZ DOMAINS; LIGHT-CHAIN; EXPRESSION; CDNA; GENE;
Keywords:
hepatocyte growth factor; Kunitz-type proteinase inhibitor; mucosal injury; experimental colitis; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Koono, M Miyazaki Med Coll, Dept Pathol 2, 500 Kihara, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll 500 Kihara Kiyotake Miyazaki Japan 8891692apan
Citazione:
H. Itoh et al., "Upregulation of HGF activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa", AM J P-GAST, 278(4), 2000, pp. G635-G643

Abstract

Hepatocyte growth factor (HGF) activator inhibitor type 1 (HAI-1) and type2 (HAI-2) are new Kunitz-type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN45 as specific inhibitors against HGF activator. Both proteins contain two Kunitz inhibitor domains and are expressed abundantly throughout the gastrointestinaltract, in addition to the placenta, pancreas, and kidney. In this study, to assess the possible roles of HAI-1 and HAI-2 in the intestinal mucosa, weexamined the expression of HAI-1 and HAI-2 during regeneration of the intestinal mucosa. Innmuno-histochemical studies revealed that HAI-1 but not HAI-2 was detected more strongly in regenerative epithelium than in normal epithelium, although both proteins were detected throughout the human gastrointestinal tract. During the course of acetic acid-induced experimental colitis in an in vivo mouse model, HAI-1 but not HAI-2 was upregulated in the recovery phase, suggesting that HAI-1 but not HAI-2 is associated with the regeneration of damaged colonic mucosa. Upregulation of HAI-1 may serve to downregulate the proliferative response after initial activation of MET receptor by HGF/scatter factor after an injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:04:37