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Titolo:
Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients
Autore:
Anduze-Faris, BM; Fillet, AM; Gozlan, J; Lancar, R; Boukli, N; Gasnault, J; Caumes, E; Livartowsky, J; Matheron, S; Leport, C; Salmon, D; Costagliola, D; Katlama, C;
Indirizzi:
Hop La Pitie Salpetriere, Dept Malad Infect & Trop, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 rop, F-75013 Paris, France Hop La Pitie Salpetriere, Dept Virol, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 rol, F-75013 Paris, France Hop St Antoine, INSERM SC4, Dept Virol, F-75571 Paris, France Hop St Antoine Paris France F-75571 4, Dept Virol, F-75571 Paris, France Hop Bicetre, Dept Med Interne, Kremlin Bictre, France Hop Bicetre KremlinBictre France t Med Interne, Kremlin Bictre, France Hop Antoine Beclere, Dept Med Interne, Clamart, France Hop Antoine Beclere Clamart France e, Dept Med Interne, Clamart, France Hop Bichat, Dept Malad Infect, F-75877 Paris, France Hop Bichat Paris France F-75877 Dept Malad Infect, F-75877 Paris, France Hop Cochin, Dept Med Interne, F-75674 Paris, France Hop Cochin Paris France F-75674 Dept Med Interne, F-75674 Paris, France
Titolo Testata:
AIDS
fascicolo: 5, volume: 14, anno: 2000,
pagine: 517 - 524
SICI:
0269-9370(20000331)14:5<517:IAMTOC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CEREBROSPINAL-FLUID; AIDS PATIENTS; ANTIRETROVIRAL THERAPY; DNA AMPLIFICATION; CMV INFECTION; GANCICLOVIR; ENCEPHALITIS; FOSCARNET; VIRUS;
Keywords:
central nervous system; cytomegalovirus; encephalitis; foscarnet; ganciclovir; HIV; myelitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Katlama, C Hop La Pitie Salpetriere, Dept Malad Infect & Trop, 45-83 Blvd Hop, F-75013 Paris, France Hop La Pitie Salpetriere 45-83 Blvd Hop Paris France F-75013 e
Citazione:
B.M. Anduze-Faris et al., "Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients", AIDS, 14(5), 2000, pp. 517-524

Abstract

Objective: To evaluate the efficacy and safety of the foscarnet-ganciclovir combination in induction therapy (IT) and maintenance therapy (MT) for cytomegalovirus (CMV) central neurological disorders in HIV-infected patients. Design: An open pilot non-comparative multicentre study. Methods: Thirty-one patients with acute CMV encephalitis (CMVe) (n = 17) or CMV myelitis (CMVm) (n =14) during the era before highly active antiretroviral therapy (HAART) received intravenous IT with foscarnet 90 mg/kg plus ganciclovir 5 mg/kg twice a day followed by MT. The primary endpoint was clinical efficacy, assessed at the end of the induction phase. Results: The foscarnet-ganciclovir combination in IT resulted in a 74% (23out of 31 patients) clinical improvement or stabilization. Eight patients did not respond clinically. Side-effects leading to drug discontinuation occurred in 10 patients during IT. Among the 23 patients who qualified for the maintenance phase, CMV disease progressed in 10, with a median rime to the first relapse of 126 days (range 64-264 days). Overall, the median survival time was 3 months [95% confidence interval (CI), 2-4 months]. Conclusion: The combination of foscarnet and ganciclovir can safely be used for CMV central nervous system (CNS) infection, with an improvement or stabilization in 74% of patients. Life-long MT with this combination is recommended as long as the immune system is profoundly impaired. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:05:57