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Titolo:
Expanded criteria donors: Attempts to increase the renal transplant donor pool
Autore:
Mandal, AK; Kalligonis, AN; Ratner, LE;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Surg, Div Surg, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 v Surg, Baltimore, MD 21205 USA
Titolo Testata:
ADVANCES IN RENAL REPLACEMENT THERAPY
fascicolo: 2, volume: 7, anno: 2000,
pagine: 117 - 130
SICI:
1073-4449(200004)7:2<117:ECDATI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADAVERIC KIDNEY-TRANSPLANTATION; MACHINE-PERFUSION PRESERVATION; PAIRED PEDIATRIC KIDNEYS; UNIVERSITY-OF-WISCONSIN; MESANGIAL IGA DEPOSITS; EURO-COLLINS SOLUTIONS; HEPATITIS-B; ADULT RECIPIENTS; PULSATILE PERFUSION; POLYCYSTIC KIDNEY;
Keywords:
renal transplantation; cadaveric organ donor; expanded criteria donor; non-heartbeating donor; dual renal transplantation; technical considerations; pulsatile perfusion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Ratner, LE Johns Hopkins Hosp, 600 N Wolfe St,Harvey 611, Baltimore, MD 21287 USA Johns Hopkins Hosp 600 N Wolfe St,Harvey 611 Baltimore MD USA 21287
Citazione:
A.K. Mandal et al., "Expanded criteria donors: Attempts to increase the renal transplant donor pool", ADV RENAL R, 7(2), 2000, pp. 117-130

Abstract

There is a growing disparity between the demand for and the supply of kidneys for transplantation. The demographics of the donor pool are also changing. The average potential cadaveric organ donor is now more likely to be older, at greater risk for co-morbid conditions such as hypertension or viralinfections, and more likely to die from cerebrovascular disease. These factors have led to an expansion of the criteria that defines the suitable organ donor. Expanded criteria donors are defined as the following: (1) at theupper and lower extremes in age; (2) having a history of hypertension or diabetes; (3) hemodynamically unstable; (4) non-heartbeating (cardiopulmonary death rather than brain death); (5) seropositive for hepatitis a or C; (6) having systemic infections; (7) having displayed high-risk social behavior for HIV infection; (8) having a history of malignancy; (9) having abnormal organ function; or (10) with renal anatomic anomalies or injuries. Use ofkidneys from these "expanded criteria donors" is a two-edged sword. While they provide more organs for transplantation, the risk of suboptimal recipient outcome is increased. A rational approach to the use of each of these types of kidneys and proper selection of recipients is essential to obtain acceptable results. The article reviews the factors that have contributed tothe successful transplantation of kidneys procured from expanded criteria organ donors and how These organs can be allocated most efficaciously to the appropriate recipients. (C) 2000 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:36:10