Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protective effects of fructose-1, 6-diphosphate against cerebral injury induced by subacute carbon monoxide intoxication in mice
Autore:
Yang, JQ; Zhou, QX;
Indirizzi:
Chongqing Univ Med Sci, Dept Biochem Pharmacol, Chongqing 400016, Peoples R China Chongqing Univ Med Sci Chongqing Peoples R China 400016 Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 4, volume: 21, anno: 2000,
pagine: 360 - 363
SICI:
0253-9756(200004)21:4<360:PEOF6A>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
learning disorders; avoidance learning; carbon monoxide poisoning; monoamine oxidase; fructosediphosphate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, JQ Chongqing Univ Med Sci, Dept Biochem Pharmacol, Chongqing 400016,Peoples R China Chongqing Univ Med Sci Chongqing Peoples R China 400016 R China
Citazione:
J.Q. Yang e Q.X. Zhou, "Protective effects of fructose-1, 6-diphosphate against cerebral injury induced by subacute carbon monoxide intoxication in mice", ACT PHAR SI, 21(4), 2000, pp. 360-363

Abstract

AIM: To study the effects of fructose-1, 6-diphosphate (FDP) on delayed cerebral injury in mice from subacute carbon monoxide (CO) exposure. METHODS:Mice were exposed to CO (100 ml/kg ip) once a day, continously for 7 d. After 7-d GO-exposure, mortality of mice, changes in learning ability anal memory using passive avoidence test, the pathomorphologic observation of brain tissue slices, and changes in monoamine oxide (MAO)-B activities in cerebral tissue were studied. FDP was administrated 30 min before GO-exposure every time. RESULTS: the preadministration of FDP markedly decreased the mortality of mice, almost reversed the impairment of learning and memory function, prevented the cells from delayed death in hippocampal neurons and blunted the rise in MAO-B activity after subacute, CO poisoning of mice. CONCLUSION: FDP pretreatment markedly prevented mice from delayed encephalophathy after CO poisoning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:24:43