Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Arterial lesions induced by phosphodiesterase III (PDE III) inhibitors andDA(1) agonists
Autore:
Joseph, EC;
Indirizzi:
Sanofi Synthelabo Res Ctr, Alnwick NE66 2JH, Northd, England Sanofi Synthelabo Res Ctr Alnwick Northd England NE66 2JH Northd, England
Titolo Testata:
TOXICOLOGY LETTERS
, volume: 112, anno: 2000,
pagine: 537 - 546
SICI:
0378-4274(20000315)112:<537:ALIBPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FENOLDOPAM MESYLATE; CARDIOVASCULAR ALTERATIONS; DOPAMINERGIC VASODILATOR; INTRAVENOUS-INFUSION; MEDIAL NECROSIS; DOGS; RATS; CARDIOTOXICITY; PATHOGENESIS; HYDRALAZINE;
Keywords:
vasodilator; arterial toxicity; haemodynamic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Joseph, EC Sanofi Synthelabo Res Ctr, Willowburn Ave, Alnwick NE66 2JH, Northd, England Sanofi Synthelabo Res Ctr Willowburn Ave Alnwick Northd England NE66 2JH
Citazione:
E.C. Joseph, "Arterial lesions induced by phosphodiesterase III (PDE III) inhibitors andDA(1) agonists", TOX LETT, 112, 2000, pp. 537-546

Abstract

Compounds that inhibit the low Km, cGMP-inhibitable form of phosphodiesterase (type III) and the DA(1) agonist, fenoldopam, are potent vasodilators that have been associated with segmental medial haemorrhagic necrosis in susceptible arterial beds following administration of suprapharmacological doses to dogs and/or rats. Morphological and haemodynamic investigative studies with PDE III inhibitors support the hypothesis that the arterial toxicityis the consequence of the vasodilator pharmacology of these compounds. Investigative data also suggest that similar mechanisms are involved in the pathogenesis of arterial lesions induced by fenoldopam and the K+ channel opener, minoxidil. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:07:36