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Titolo:
Promoters and promotion of axonopathies
Autore:
Moretto, A;
Indirizzi:
Univ Padua, Ist Med Lavoro, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 dua, Ist Med Lavoro, I-35128 Padua, Italy
Titolo Testata:
TOXICOLOGY LETTERS
, volume: 112, anno: 2000,
pagine: 17 - 21
SICI:
0378-4274(20000315)112:<17:PAPOA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPATHY TARGET ESTERASE; INDUCED DELAYED NEUROTOXICITY; PHENYL VALERATE ESTERASES; ORGANOPHOSPHATE POLYNEUROPATHY; PHENYLMETHANESULFONYL FLUORIDE; PHENYLMETHYLSULFONYL FLUORIDE; CLINICAL EXPRESSION; SCIATIC-NERVE; PATHOGENESIS; POTENTIATION;
Keywords:
esterase; inhibitor; nervous system; repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Moretto, A Univ Padua, Ist Med Lavoro, Via Giustiniani 2, I-35128 Padua, Italy Univ Padua Via Giustiniani 2 Padua Italy I-35128 Padua, Italy
Citazione:
A. Moretto, "Promoters and promotion of axonopathies", TOX LETT, 112, 2000, pp. 17-21

Abstract

Promotion is the exacerbation by certain esterase inhibitors (organophosphates, organophosphinates, sulfonyl halides, carbamates and thiocarbamates) of the clinical and morphological expression of toxic and traumatic axonopathies. Promotion is believed to interfere with mechanisms of compensation/repair of the nerves. The target of promotion is unknown but there are indications that it might be similar and/or linked to neuropathy target esterase(NTE), which is the molecular target of organophosphate-induced delayed polyneuropathy (OPIDP). OPIDP is the model axonopathy used to characterize promotion. NTE is defined as the activity resistant to paraoxon (40 mu M) andsensitive to mipafox (50 mu M). An esterase activity sensitive to higher concentrations (1 mM) of mipafox was identified in the nervous system homogenate, and its inhibition correlated with promotion. An activity with similar characteristics was present in the soluble fraction of peripheral nerves and could be physically separated (about 60 kDa). Identification and characterization of the target of promotion might be helpful in understanding themechanism(s) of compensation and repair of the peripheral nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 08:34:16