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Titolo:
Syntheses of 1,2,4-triazolo[4,3-c]pteridines. Potential substrates for xanthine oxidase
Autore:
Kraus, W; van der Plas, HC;
Indirizzi:
Polish Acad Sci, Inst Catalysis & Surface Chem, PL-30239 Krakow, Poland Polish Acad Sci Krakow Poland PL-30239 ace Chem, PL-30239 Krakow, Poland Agr Univ Wageningen, Dept Organ Chem, NL-6700 HB Wageningen, Netherlands Agr Univ Wageningen Wageningen Netherlands NL-6700 HB ingen, Netherlands
Titolo Testata:
TOPICS IN CATALYSIS
fascicolo: 1-4, volume: 11, anno: 2000,
pagine: 409 - 417
SICI:
1022-5528(2000)11:1-4<409:SO1PSF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYMES; PTERIDINES; INHIBITORS; OXIDATION;
Keywords:
bacterial xanthine oxidase; enzymatic oxidation; enzyme inhibition; pteridine derivatives; 1,2,4-triazolo[4,3-c]pteridine synthesis; s-triazolopyrimidine moiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kraus, W Polish Acad Sci, Inst Catalysis & Surface Chem, Niezapominajek Str, PL-30239 Krakow, Poland Polish Acad Sci Niezapominajek Str Krakow Poland PL-30239 Poland
Citazione:
W. Kraus e H.C. van der Plas, "Syntheses of 1,2,4-triazolo[4,3-c]pteridines. Potential substrates for xanthine oxidase", TOP CATAL, 11(1-4), 2000, pp. 409-417

Abstract

A synthetic route for the preparation of 9-phenyl-1,2,4-triazolo[4,3-c]pteridines 8 is described. Their reactivities towards xanthine oxidase from Arthrobacter M-4 are determined and compared with the pteridine derivatives 6-phenylpteridin-4[3H]-thione 5, 6-phenyl-4-thiomethylpteridine 6, 4-hydrazino-6-phenylpteridine 7, 3-N-methyl-6-phenylpteridin-4[3H]-thione 19, 4-amino-6-phenylpteridine 22 and 1-N-methyl-6-phenylpteridin-4[1H]-one 24, in order to inspect a possible influence of pyrimidine ring substitution pattern on their interaction with the bacterial enzyme. It has been suggested that a planar structure of the pteridine moiety and the substituents could be animportant factor that so far has been overlooked when considering the enzyme activity. Some literature data are also discussed in view of revision ofstructure assignment of the compounds 12, 14, and 17.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:19:35