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Titolo:
Therapeutic drug monitoring of tacrine: Simple and fast high-performance liquid chromatography assay method for its determination in human plasma
Autore:
Chollet, DF; Castella, E; Anderegg, G; Arnera, V; Hadler, D;
Indirizzi:
Covance CLS SA, Bioanalyt Div, CH-1217 Meyrin Geneva, Switzerland Covance CLS SA Meyrin Geneva Switzerland CH-1217 rin Geneva, Switzerland Takeda Euro R&D Ctr, Frankfurt, Germany Takeda Euro R&D Ctr Frankfurt Germany Euro R&D Ctr, Frankfurt, Germany
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 2, volume: 22, anno: 2000,
pagine: 225 - 229
SICI:
0163-4356(200004)22:2<225:TDMOTS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; FLUORESCENCE DETECTION; HUMAN-SERUM; HYDROCHLORIDE; METABOLITES; URINE;
Keywords:
tacrine; high-performance liquid chromatography drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Chollet, DF Covance CLS SA, Bioanalyt Div, Rue Moise Marcinhes 7, CH-1217 Meyrin Geneva, Switzerland Covance CLS SA Rue Moise Marcinhes 7 Meyrin Geneva Switzerland CH-1217
Citazione:
D.F. Chollet et al., "Therapeutic drug monitoring of tacrine: Simple and fast high-performance liquid chromatography assay method for its determination in human plasma", THER DRUG M, 22(2), 2000, pp. 225-229

Abstract

A new high-performance liquid chromatography (HPLC) assay method was developed for the therapeutic monitoring of tacrine. The method involved a simple protein precipitation by means of either acetonitrile or cold methanol followed by a fast isocratic separation on a CN column eluted in reversed-phase mode. The entire sample preparation took place in an HPLC vial and no further liquid transfer was required. The validation data showed that the assay method was precise, accurate, and robust. Analysis of more than 1,000 plasma samples collected from patients with Alzheimer disease demonstrates the suitability of the assay.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:57:57