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Titolo:
Venlafaxine serum levels and CYP2D6 genotype
Autore:
Veefkind, AH; Hafmans, PMJ; Hoencamp, E;
Indirizzi:
Psychiat Ctr Zon & Schild, Dept Clin Chem, NL-3800 DB Amersfoot, Netherlands Psychiat Ctr Zon & Schild Amersfoot Netherlands NL-3800 DB , Netherlands Parnassia Psychiat Ctr, The Hague, Netherlands Parnassia Psychiat Ctr TheHague Netherlands tr, The Hague, Netherlands
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 2, volume: 22, anno: 2000,
pagine: 202 - 208
SICI:
0163-4356(200004)22:2<202:VSLACG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE; ANTIDEPRESSANTS; POPULATION; METABOLISM;
Keywords:
venlafaxine; plasma concentrations; CYP2D6; poor metabolizers; ultrarapid metabolizers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Veefkind, AH Psychiat Ctr Zon & Schild, Dept Clin Chem, POB 3051, NL-3800 DB Amersfoot,Netherlands Psychiat Ctr Zon & Schild POB 3051 Amersfoot Netherlands NL-3800 DB
Citazione:
A.H. Veefkind et al., "Venlafaxine serum levels and CYP2D6 genotype", THER DRUG M, 22(2), 2000, pp. 202-208

Abstract

Thirty-three patients with depression treated with 225 mg venlafaxine weregenotyped for the polymorphic enzyme, debrisoquine 4-hydroxylase (CYP2D6). The relationship between drug and metabolite levels and between genotype and clinical response were investigated. Although the number of responders in this study is insufficient for definite conclusions to be drawn, a targettherapeutic concentration ranging from 195-400 mu g/L for the sum of venlafaxine and O-desmethylvenlafaxine is suggested. The ratio of O-desmethylvenlafaxine to venlafaxine in the serum concentrations is a measure of metabolic turnover, and can be used to distinguish between ultrarapid and poor metabolizers. All but one of the nonresponders in this study had lower ratios than the responders. Three patients (9%) had homozygous defective CYP2D6 alleles and did not readily metabolize venlafaxine to O-desmethylvenlafaxine,pointing to poor metabolism. In these patients, N-desmethylation was increased. Two out of four patients detected by the ratio as potentially ultrarapid metabolizers were shown to have multiple copies of a functional CYP2D6 gene.

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Documento generato il 27/01/20 alle ore 01:25:06