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Titolo:
Simultaneous plasma level analysis of clomipramine, N-desmethylclomipramine, and fluvoxamine by reversed-phase liquid chromatography
Autore:
Palego, L; Marazziti, D; Biondi, L; Giannaccini, G; Sarno, N; Armani, A; Lucacchini, A; Cassano, GB; DellOsso, L;
Indirizzi:
Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 urobiol Farmacol & Bio, I-56100 Pisa, Italy
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 2, volume: 22, anno: 2000,
pagine: 190 - 194
SICI:
0163-4356(200004)22:2<190:SPLAOC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; ULTRAVIOLET DETECTION; CLINICAL-RESPONSE; PANIC DISORDER; IMIPRAMINE; METABOLITES; DEPRESSION;
Keywords:
clomipramine; N-desmethylclomipramine; fluvoxamine; dibenzepine; RPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Palego, L Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, Via Bonanno 6, I-56100 Pisa, Italy Univ Pisa Via Bonanno 6 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
L. Palego et al., "Simultaneous plasma level analysis of clomipramine, N-desmethylclomipramine, and fluvoxamine by reversed-phase liquid chromatography", THER DRUG M, 22(2), 2000, pp. 190-194

Abstract

A simple reversed-phase liquid chromatographic method enabling the simultaneous analysis in plasma of the tricyclic antidepressant clomipramine, its demethylated metabolite, and the selective serotonin reuptake inhibitor fluvoxamine, was developed: The drugs and dibenzepine, the internal standard, were extracted from 1 mL. plasma through an automated solid-phase procedure, eluted in a total chromatographic time of approximately 14 min and detected by means of an ultraviolet spectrophotometer preset at 254 nm. An assay sensitivity of 10 mu g/L was observed for all analytes, Recoveries for these drugs and their metabolites ranged between 65% and 98% and. their coefficient of variation (within-day and day-to-day) between 1.9% and 2.9%. In spiked plasma, within-day and day-to-day imprecision data were less than 5%. The simultaneous determination of clomipramine, N-desmethylclomipratnine, and fluvoxamine with adequate sensitivity and accuracy may be useful for the monitoring of drug treatment in depression and obsessive-compulsive disorder, where combinations of such drugs are employed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:41:46