Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Specialized fatty acid synthesis in African trypanosomes: Myristate for CPI anchors
Autore:
Morita, YS; Paul, KS; Englund, PT;
Indirizzi:
Johns Hopkins Med Sch, Dept Biol Chem, Baltimore, MD 21205 USA Johns Hopkins Med Sch Baltimore MD USA 21205 hem, Baltimore, MD 21205 USA
Titolo Testata:
SCIENCE
fascicolo: 5463, volume: 288, anno: 2000,
pagine: 140 - 143
SICI:
0036-8075(20000407)288:5463<140:SFASIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIANT SURFACE GLYCOPROTEIN; BIOLOGICAL PROPERTIES; BIOSYNTHESIS; BRUCEI; THIOLACTOMYCIN; METABOLISM; BLOOD; FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Englund, PT Johns Hopkins Med Sch, Dept Biol Chem, Baltimore, MD 21205 USAJohns Hopkins Med Sch Baltimore MD USA 21205 re, MD 21205 USA
Citazione:
Y.S. Morita et al., "Specialized fatty acid synthesis in African trypanosomes: Myristate for CPI anchors", SCIENCE, 288(5463), 2000, pp. 140-143

Abstract

African trypanosomes, the cause of sleeping sickness, need massive amountsof myristate to remodel glycosyl phosphatidylinositol (GPI) anchors on their surface glycoproteins. However, it has been believed that the parasite is unable to synthesize any fatty acids, and myristate is not abundant in the hosts' bloodstreams. Thus, it has been unclear how trypanosomes meet their myristate requirement. Here we found that they could indeed synthesize fatty acids. The synthetic pathway was unique in that the major product, myristate, was preferentially incorporated into GPIs and not into other lipids. The antibiotic thiolactomycin inhibited myristate synthesis and killed theparasite, making this pathway a potential chemotherapeutic target.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:49:54