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Titolo:
Polymorphism in the promoter region of the alpha(2A)-adrenergic receptor gene and panic disorders
Autore:
Ohara, K; Suzuki, Y; Ochiai, M; Terada, H; Ohara, K;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Psychiat, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 1, volume: 93, anno: 2000,
pagine: 79 - 82
SICI:
0165-1781(20000214)93:1<79:PITPRO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED ANXIETY DISORDER; NORADRENERGIC FUNCTION; HEALTHY-SUBJECTS; YOHIMBINE; SUBTYPES; ATTACKS; BINDING;
Keywords:
genetics; anxiety; promoter; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ohara, K Shinshiro Municipal Hosp, Dept Psychiat, 32-1 Kitahata, Aichi 4411387, Japan Shinshiro Municipal Hosp 32-1 Kitahata Aichi Japan 4411387 Japan
Citazione:
K. Ohara et al., "Polymorphism in the promoter region of the alpha(2A)-adrenergic receptor gene and panic disorders", PSYCHIAT R, 93(1), 2000, pp. 79-82

Abstract

alpha(2)-adrenergic receptors have been thought to play a crucial role in the etiology or treatment of panic disorders. Polymorphism(s) in the promoter region of the alpha(2) receptor may affect gene expression and be associated with panic disorders. We studied the polymorphism of the alpha(2A) receptor gene at position - 1291 reported by Lario et al. (Lario, S., Calls, J., Cases, A., Oriola, J., Torras, A.: Rivera, F., 1997. Short repeat on DNAmarker at candidate locus. MspI identifies a biallelic polymorphism in thepromoter region of the alpha(2A)-adrenergic receptor gene. Clinical Genetics 51, 129-130.) in 114 healthy control subjects and 55 patients with panicdisorders. There was no statistically significant difference between controls and patients in either genotype or allele frequency. Our results suggest there is no association between this polymorphism in the promoter region of the alpha(2A) receptor gene and panic disorders. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:57:59