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Titolo:
Anti-interleukin-8 auto-antibodies in cerebrospinal fluid of children withpurulent meningitis
Autore:
Takasaki, J; Ogawa, Y;
Indirizzi:
Saitama Med Sch, Saitama Med Ctr, Dept Pediat, Kawagoe, Saitama 3508550, Japan Saitama Med Sch Kawagoe Saitama Japan 3508550 goe, Saitama 3508550, Japan
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 2, volume: 42, anno: 2000,
pagine: 139 - 142
SICI:
1328-8067(200004)42:2<139:AAICFO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; BACTERIAL-MENINGITIS; INTERLEUKIN-8; AUTOANTIBODIES; BLOOD;
Keywords:
auto-antibody; cerebrospinal fluid; interleukin-8; meningitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Takasaki, J Saitama Med Sch, Saitama Med Ctr, Dept Pediat, 1981 Kamoda Tsujido, Kawagoe, Saitama 3508550, Japan Saitama Med Sch 1981 Kamoda Tsujido Kawagoe Saitama Japan 3508550
Citazione:
J. Takasaki e Y. Ogawa, "Anti-interleukin-8 auto-antibodies in cerebrospinal fluid of children withpurulent meningitis", PEDIATR INT, 42(2), 2000, pp. 139-142

Abstract

Background: Cerebrospinal fluid (CSF) of patients with purulent meningitiscontains a high concentration of interleukin (IL)-8. Recently, the presence of anti-IL-8 auto-antibodies was noted in blood and alveolar fluid. Therefore, measurement of the concentration of anti-IL-8 auto-antibodies was attempted in CSF of children with and without meningitis. Methods and Results: We measured the concentration of anti-IL-8 auto-antibodies in CSF of children with purulent or aseptic meningitis and those without meningitis. The CSF obtained on admission showed a significantly higherconcentration of anti-IL-8 IgG and IgM auto-antibodies in children with purulent meningitis, compared with those with aseptic meningitis or without meningitis. Among the three groups of children, the concentration of IL-8 was also significantly higher in CSF of children with purulent meningitis. Conclusion: Because the anti-IL-8 IgG auto-antibody binds to IL-8 and inhibits IL-8 interaction with specific receptors on neutrophils, the presence of anti-IL-8 auto-antibodies seems to provide a mechanism that limits the bioavailability of free IL-8 in CSF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:00:08