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Titolo:
Fetal obstructive uropathy: Patterns of renal pathology
Autore:
Poucell-Hatton, S; Huang, M; Bannykh, S; Benirschke, K; Masliah, E;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Univ Calif San Diego, San Diego Med Ctr, Dept Pathol, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 thol, San Diego, CA 92103 USA
Titolo Testata:
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
fascicolo: 3, volume: 3, anno: 2000,
pagine: 223 - 231
SICI:
1093-5266(200005/06)3:3<223:FOUPOR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRUNE-BELLY SYNDROME; HUMAN KIDNEY MALFORMATIONS; DNA FRAGMENTATION; EXPRESSION; PATHOGENESIS; URINARY; DISEASE; FETUS; PAX2;
Keywords:
urethral obstruction; apoptosis; cytokeratin; prune-belly syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Masliah, E Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
S. Poucell-Hatton et al., "Fetal obstructive uropathy: Patterns of renal pathology", PEDIATR D P, 3(3), 2000, pp. 223-231

Abstract

Fetal obstructive uropathy (FOU) is characterized by obstruction of the urethra, renal anomalies, ureterovesical dilatation, oligohydramnios, cryptorchidism, and abdominal muscle wall changes. The main objective of the present study was to better understand the relationship between FOU and renal pathology using a series of 15 male autopsy cases. A total of 11 cases with patent anus and 4 with imperforate anus were analyzed. Of the first group, most cases showed obstruction at the level of prostatic urethra. Seven casesshowed obstruction at the level of the prostatic urethra and histologic study revealed scarring and partial or complete absence of the prostate, while in the remaining four cases the prostate was present. Of the cases with imperforate anus, two showed obstruction at the level of prostatic urethra, one showed posterior urethral valves, and one was obstructed at the proximal urethra. In all cases the kidneys showed mixed (dysplastic and cystic) changes with no significant differences between the two groups. An inverse correlation was observed between degree of renal dysplasia and gestational age, whereas the opposite was true for cystic changes. Distal and collecting tubules were more intensely immunoreactive to the anti-cytokeratin antibodywhen compared to proximal tubules. Moreover, anti-cytokeratin immunoreactivity was more prominent in tubules displaying cystic dilatation. DNR fragmentation analysis of renal tissue revealed a higher apoptosis of mesenchymaland tubular cells in the FOU cases, compared to gestational aged-matched controls. These results suggest that renal anomalies in FOU might be relatedto the gestational age at which the injury occurred and to the duration ofthe obstruction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:17:11