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Titolo:
P2 purinoceptor expression and functional changes of hypoxia-activated cultured rat retinal microglia
Autore:
Morigiwa, K; Quan, MZ; Murakami, M; Yamashita, M; Fukuda, Y;
Indirizzi:
Osaka Univ, Dept Physiol & Biosignalling A5, Grad Sch Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Sch Med, Suita, Osaka 5650871, Japan Nara Med Univ, Dept Physiol 1, Kashihara, Nara 6348521, Japan Nara Med Univ Kashihara Nara Japan 6348521 Kashihara, Nara 6348521, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 282, anno: 2000,
pagine: 153 - 156
SICI:
0304-3940(20000324)282:3<153:PPEAFC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; EXTRACELLULAR ATP; CEREBRAL-ISCHEMIA; CELLS; INTERLEUKIN-1-BETA; RESPONSES; RELEASE; BRAIN;
Keywords:
rat retina; microglia; hypoxia; P-2U (P2Y(2); P2Y(4)); P-2Z (P2X(7)); proliferation; tumor necrosis factor-alpha; interleukin-1 beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Morigiwa, K Osaka Univ, Dept Physiol & Biosignalling A5, Grad Sch Med, 2-2Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
K. Morigiwa et al., "P2 purinoceptor expression and functional changes of hypoxia-activated cultured rat retinal microglia", NEUROSCI L, 282(3), 2000, pp. 153-156

Abstract

P2 purinoceptors appear to modulate microglia function, but their role in hypoxic microglia has not been investigated. We examined in postnatal rat retinal microglia cultured under hypoxic (1% oxygen) condition, their P2 expression, proliferation and cytokine release in the presence or absence of the P2 receptor agonists and antagonists. Fura-2 fluorescence measurements of intracellular Ca2+ rises to P2 receptor agonists and antagonists indicated that both P-2U and P-2Z were expressed in hypoxic microglia. Hypoxia induced BrdU incorporation and release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) as well. The P-2U agonist, UTP, maintained the BrdU incorporation, whereas the P2Z agonist, BzATP, suppressed it, but significantly enhanced IL-1 beta and TNF-alpha release, suggesting that the P-2U response may underlie the mitotic activity, a nd that of P-2Z, the IL-1 beta and TNF-alpha release of hypoxia-activated microglia. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 10:00:58