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Titolo:
A genetic analysis of synaptic development: Pre- and postsynaptic dCBP control transmitter release at the Drosophila NMJ
Autore:
Marek, KW; Ng, N; Fetter, R; Smolik, S; Goodman, CS; Davis, GW;
Indirizzi:
Univ Calif San Francisco, Sch Med, Dept Biochem & Biophys, Cell Biol Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sch Med, Dept Biochem & Biophys, Program Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA Oregon Hlth Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 v Biol, Portland, OR 97201 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 25, anno: 2000,
pagine: 537 - 547
SICI:
0896-6273(200003)25:3<537:AGAOSD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RUBINSTEIN-TAYBI-SYNDROME; FUNCTIONAL COMPONENTS; CREB PHOSPHORYLATION; RETROGRADE SIGNAL; MEMORY; CBP; PLASTICITY; FACILITATION; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, GW Univ Calif San Francisco, Sch Med, Dept Biochem & Biophys, Cell Biol Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 A 94143 USA
Citazione:
K.W. Marek et al., "A genetic analysis of synaptic development: Pre- and postsynaptic dCBP control transmitter release at the Drosophila NMJ", NEURON, 25(3), 2000, pp. 537-547

Abstract

Postsynaptic dCBP (Drosophila homolog of the CREB binding protein) is required for presynaptic functional development. Viable, hypomorphic dCBP mutations have a similar to 50% reduction in presynaptic transmitter release without altering the Ca2+ cooperativity of release or synaptic ultrastructure (total bouton number is increased by 25%-30%). Exogenous expression of dCBPin muscle rescues impaired presynaptic release in the dCBP mutant background, while presynaptic dCBP expression does not. In addition, overexpressionexperiments indicate that elevated dCBP can also inhibit presynaptic functional development in a manner distinct from the effects of dCBP loss of function. Pre- or postsynaptic overexpression of dCBP (in wild type) reduces presynaptic release. However, we do not observe an increase in bouton number, and presynaptic overexpression impairs short-term facilitation. These data suggest that dCBP participates in a postsynaptic regulatory system that controls functional synaptic development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:02:10