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Titolo:
Modalities of fatigue in multiple sclerosis: correlation with clinical andbiological factors
Autore:
Iriarte, J; Subira, ML; de Castro, P;
Indirizzi:
Univ Navarra Clin, Dept Neurol, Pamplona 31080, Spain Univ Navarra Clin Pamplona Spain 31080 ept Neurol, Pamplona 31080, Spain Univ Navarra Clin, Dept Immunol, Pamplona 31080, Spain Univ Navarra Clin Pamplona Spain 31080 pt Immunol, Pamplona 31080, Spain
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 2, volume: 6, anno: 2000,
pagine: 124 - 130
SICI:
1352-4585(200004)6:2<124:MOFIMS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; MOTOR EVOKED-POTENTIALS; POSTEXERCISE FACILITATION; NEUROLOGICAL DISORDERS; MUSCLE FATIGUE; DOUBLE-BLIND; DEPRESSION; TRIAL; INSTRUMENT; AMANTADINE;
Keywords:
fatigue; multiple sclerosis; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Iriarte, J Univ Navarra Clin, Dept Neurol, Pamplona 31080, Spain Univ Navarra Clin Pamplona Spain 31080 Pamplona 31080, Spain
Citazione:
J. Iriarte et al., "Modalities of fatigue in multiple sclerosis: correlation with clinical andbiological factors", MULT SCLER, 6(2), 2000, pp. 124-130

Abstract

Although different factors ore probably involved in the etiology of fatigue in multiple sclerosis patients, no definite mechanism has been proposed We have proposed that fatigue is a complex symptom that includes three clinical different entities (asthenia, fatigability and worsening of symptoms with effort). The goal of this study is to demonstrate if there is a peculiarmechanism for each of the different varieties of fatigue. A control sampleof 155 patients (105 women, 50 men) with clinically definite MS was studied. Fatigue was measured using the Fatigue Descriptive Scale (FDS) and the Fatigue Severity Scale (FSS). Treatment, depression, anxiety sleep and cellular immune status were studied too. Fatigue was a symptom in 118 patients (76.13%); 26 patients (22.03%) described it as asthenia (fatigue at rest); 85 patients (72.03%) as fatigability (fatigue with exercise), and seven patients (5.9%) as worsening of symptoms. The severity of pyramidal involvementwas significantly more severe in patients suffering from fatigue; some immunological Parameters were associated with fatigue as well. The discriminant analysis of the data shows that some of the immunoactivation parameters ore associated with asthenia (F=21.5, P < 0.001), and pyramidal trace involvement is associated with fatigability (F=10.5, P < 0.001). Sleep disorders,anxiety and depression were linked with fatigue in a few patients. No relationship with treatment was proven. In conclusion, fatigue in MS seems to be a heterogeneous entity. Asthenia and fatigability may be different clinical entities. Certain immunoactivation parameters correlate with the presence of asthenia while pyramidal involvement is associated with fatigability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:26:30