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Titolo:
EFFECT OF GRADED HYPOTHERMIA (27-DEGREES TO 34-DEGREES-C) ON BEHAVIORAL FUNCTION, HISTOPATHOLOGY, AND SPINAL BLOOD-FLOW AFTER SPINAL ISCHEMIA IN RAT
Autore:
MARSALA M; VANICKY I; YAKSH TL;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,ANESTHESIOL RES LAB,9500 GILMANDR LA JOLLA CA 92093 SLOVAK ACAD SCI,INST NEUROBIOL KOSICE 04001 SLOVAKIA
Titolo Testata:
Stroke
fascicolo: 10, volume: 25, anno: 1994,
pagine: 2038 - 2046
SICI:
0039-2499(1994)25:10<2038:EOGH(T>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL SLICES; BRAIN TEMPERATURE; MILD HYPOTHERMIA; NEURONAL DEATH; CO2 REACTIVITY; CORD ISCHEMIA; CNS ISCHEMIA; PROTECTION; RABBITS; GERBIL;
Keywords:
HYPOTHERMIA; NEURONS, ARGYROPHILIC; PARAPLEGIA; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Marsala et al., "EFFECT OF GRADED HYPOTHERMIA (27-DEGREES TO 34-DEGREES-C) ON BEHAVIORAL FUNCTION, HISTOPATHOLOGY, AND SPINAL BLOOD-FLOW AFTER SPINAL ISCHEMIA IN RAT", Stroke, 25(10), 1994, pp. 2038-2046

Abstract

Background and Purpose We used a rat model of reversible spinal ischemia to assess the effect of spinal cord temperature on the developmentof neurological and histopathologic changes after 20 minutes of reversible aortic occlusion. Spinal cord blood flow and CO2 reactivity was tested by using laser Doppler before and 60 minutes after ischemia. Methods In halothane (1%)-anesthetized rats, the spinal cord temperatureas assessed by using thermocouple in the paraspinal muscles was lowered to 34 degrees, 31 degrees, or 27 degrees C. After ischemia, spinal cord temperature was raised to 37 degrees C for the next 30 minutes. Animals were maintained in this normothermic condition for 8 hours, after which motor and sensory function were assessed. All animals were then anesthetized and perfused with 10% formalin for light microscopic analysis of spinal cords. Results In normothermic animals, 20 minutes of ischemia resulted in a loss of CO2 reactivity and hind limb paraplegia with an attendant allodynia that persisted for the 8 hours of reperfusion. Even mild (34 degrees C) hypothermia resulted in significant improvement of neurological function compared with the normothermic group. In paraplegic animals, lumbosacral interneuronal pools localized primarily in laminae III through W displayed heavy argyrophilic neuronsand areas of localized necrosis. In moderate and deep hypothermic animals preservation of CO2 responsivity and complete recovery of neurological function were seen with no detectable histopathologic changes. Conclusions These results show that a slight decrease in spinal cord temperature in the peri-ischemic period provides significant protection as measured by histopathology and neurological function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:21:36