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Titolo:
Statistical models for predicting response to interferon-alpha and spontaneous seroconversion in children with chronic hepatitis B
Autore:
Comanor, L; Minor, J; Conjeevaram, HS; Roberts, EA; Alvarez, F; Bern, EM; Goyens, P; Rosenthal, P; Lachaux, A; Shelton, M; Sarles, J; Sokal, EM;
Indirizzi:
Bayer Diagnost, Emeryville, CA USA Bayer Diagnost Emeryville CA USABayer Diagnost, Emeryville, CA USA Univ Chicago Hosp, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA60637 hicago Hosp, Chicago, IL 60637 USA Hosp Sick Children, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Hop St Justine, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 e, Montreal, PQ H3T 1C5, Canada Univ Massachusetts, Med Ctr, Worcester, MA USA Univ Massachusetts Worcester MA USA chusetts, Med Ctr, Worcester, MA USA Hop Enfants Reine Fabiola, Brussels, Belgium Hop Enfants Reine Fabiola Brussels Belgium e Fabiola, Brussels, Belgium Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Hop Edouard Herriot, Lyon, France Hop Edouard Herriot Lyon FranceHop Edouard Herriot, Lyon, France Cook Childrens Med Ctr, Ft Worth, TX USA Cook Childrens Med Ctr Ft Worth TX USA ildrens Med Ctr, Ft Worth, TX USA Hop Enfants La Timone, Marseille, France Hop Enfants La Timone MarseilleFrance nts La Timone, Marseille, France Catholic Univ Louvain, Clin St Luc, Brussels, Belgium Catholic Univ Louvain Brussels Belgium , Clin St Luc, Brussels, Belgium
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 2, volume: 7, anno: 2000,
pagine: 144 - 152
SICI:
1352-0504(200003)7:2<144:SMFPRT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; CHRONIC VIRAL-HEPATITIS; E-ANTIGEN; SURFACE-ANTIGEN; THERAPY; METAANALYSIS; DNA; QUANTIFICATION; ANTIBODIES; INFECTION;
Keywords:
HBV DNA; IFN-alpha therapy; paediatrics; SMILES prognostic models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Comanor, L Bayer Diagnost, 1801 Waverley St, Palo Alto, CA 94301 USA BayerDiagnost 1801 Waverley St Palo Alto CA USA 94301 4301 USA
Citazione:
L. Comanor et al., "Statistical models for predicting response to interferon-alpha and spontaneous seroconversion in children with chronic hepatitis B", J VIRAL HEP, 7(2), 2000, pp. 144-152

Abstract

To develop prognostic models for identifying children with hepatitis B whoare likely to respond to interferon-alpha (IFN-alpha) or to spontaneously seroconvert, we evaluated results of a multinational controlled trial comprising 70 children with chronic hepatitis B who received IFN-alpha and 74 children who did not receive therapy. Prognostic models were developed using SMILES (similarity of least squares), which is a data analysis network thatincorporates multidimensional relationships in the clinical data of complex diseases. Commonly collected clinical data included age, gender, serum aminotransferase (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) and hepatitis B virus (HBV) DNA levels, and IFN-alpha dose. Additional data included pretreatment directional information (e.g. increases ordecreases in serum aminotransferase and HBV DNA levels), liver biopsy results, race and transmission mode. Using data available prior to initiation of treatment, the SMILES models achieved prospective predictions of 89% for responders, 96% for non-responders, 100% for seroconverters and 93% for non-seroconverters. Although not predictive by themselves, the variables that had the greatest impact on predictions for IFN-alpha response were HBV DNA pretreatment direction, baseline HBV DNA, IFN-alpha dose and gender. The variables that had the greatest impact on predictions for spontaneous seroconversion were ALT pretreatment direction, baseline HBV DNA level, age and AST pretreatment direction. Therefore, these models may be useful in determining, in children with hepatitis B, the likelihood of response to IFN-alpha and spontaneous seroconversion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:38:02